Pancreatic β-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study

Abstract

Beta-cell function as measured by HOMA-%B is a significant predictor of incident cardiovascular events and mortality but not of costs, controlling for HOMA-%S and sociodemographic and clinical confounders.

Coronary heart disease risk factors in adult premenopausal white women with polycystic ovary syndrome compared with a healthy female population

“…This suggests that pioglitazone-mediated reduction of insulin resistance may slow the progression of CAD [35]. In a study of 4555 elderly subjects, β-cell function as measured by HOMA-B was a significant predictor of incident cardiovascular events and mortality after controlling for HOMA-IR and sociodemographic and clinical confounders [36].…”

Association between β‐cell function estimated by HOMA‐β and prognosis of non‐diabetic patients with ischaemic stroke

“…Previous studies [6,7] have focused on the relationship between b-cell function and cardiovascular events. The Cardiovascular Health Study [6] stated that lower HOMA-b levels were significantly associated with an increased risk of incident coronary heart disease, myocardial infarction, but it was not a significant predictor of incident stroke or transient ischaemic attack. Wang et al [7] once measured b-cell function by disposition index, addressing that decreased b-cell function was closely related to the presence of coronary artery disease in those with normal glucose tolerance.…”

“…Previous studies have focused on the relationship between β‐cell function and cardiovascular events. The Cardiovascular Health Study stated that lower HOMA‐β levels were significantly associated with an increased risk of incident coronary heart disease, myocardial infarction, but it was not a significant predictor of incident stroke or transient ischaemic attack. Wang et al .…”

“…At the end of 1 year after stroke onset, follow-up was conducted through telephone calls for all recruited patients based on a shared standardized interview protocol. The outcomes included stroke recurrence (aggravated primary neurological deficit, development of new signs, re-hospitalization caused by ischaemic or haemorrhagic stroke) [4], poor functional outcome [modified Rankin Scale (mRS) score of [3][4][5][6] [15] and all-cause mortality at 1 year.…”

“…Insulin resistance is related to an increased risk of cardiovascular disease and stroke in people with normal glucose tolerance [3] as well as with clinical outcome (s) of non-diabetic ischaemic stroke [4,5]. Previous studies have shown an association between b-cell function and cardiovascular events [6,7]. However, no significant association between b-cell function and incidence of stroke or transient ischaemic attack was found.…”