Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

Sun, Jia; Furio, Laetitia; Mecheri, Ramine; Does, Anne M. van der; Lundeberg, Erik; Saveanu, Loredana; Chen, Yong Q.; Endert, Peter Van; Agerberth, Birgitta; Diana, James S.

doi:10.1016/j.immuni.2015.07.013

Cited by 251 publications

(295 citation statements)

References 53 publications

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“…These results therefore suggest a dichotomy in tTreg and pTreg function: tTreg, presumably specific for self-antigens, would protect the organism from autoimmune disease, whereas pTreg, presumably specific for non-self-antigens found in the mucosa, would avoid chronic inflammation. However, pTreg are also known to inhibit autoimmune (type 1) diabetes in mice, showing that this separation of functions of tTreg versus pTreg, if largely confirmed, is not absolute [15] .…”

Section: Functions Of Ttreg and Ptregmentioning

confidence: 99%

Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review

Darrigues¹,

Meerwijk²,

Romagnoli³

2017

Gerontology

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The generation and function of immuno-suppressive regulatory T lymphocytes (Treg), which can differentiate in the thymus (tTreg) or in the periphery (pTreg), are regulated in an age-dependent manner. tTreg are produced at high levels in the first weeks of age, when they expand and colonize secondary lymphoid organs and peripheral tissues to protect the organism from autoimmune diseases and to promote tissue repair. Once this population of Treg is operational in the periphery, at puberty, thymic output of Treg declines, but self-reactive tTreg generated early on in life are maintained over time and play a major role in preserving homeostasis of the immune system. Extra-thymic pTreg differentiation declines later on in life. pTreg generated throughout life mainly protect the organism from chronic inflammation and the semi-allogeneic fetus from rejection. In this review, age-dependent modulation of the production and function of these two populations of Treg is described.

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Section: Functions Of Ttreg and Ptregmentioning

confidence: 99%

Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review

Darrigues¹,

Meerwijk²,

Romagnoli³

2017

Gerontology

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“…Modulation in CRAMP production leads to inflammation of pancreatic islets and development of autoimmune diabetes. This was observed clearly in an animal model [16].…”

Section: Jayaswal Et Almentioning

confidence: 56%

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Vijayasimha

Prabhakar

2018

Asian J Pharm Clin Res

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In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing development of Type 1 (T1D) and Type 2 diabetes (T2D) in humans and laboratory animals. The available data we found are still inconclusive and required more attention in discriminating specific groups of gut microbiomes strongly indicating T1D and T2D development or prevention. Further, we suggested for the first time to study the gut microbiota in different ways to find the root cause of diabetes development.

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“…Several recent studies demonstrated that gut microbiota play a pivotal role in the pathogenesis of not only gastrointestinal diseases but also systemic diseases such as diabetes mellitus, cardiovascular disease, arthritis, and obesity [7,8,9,10]. Probiotics are also well known for their usefulness in improving immune function, preventing diarrhea, and reducing blood glucose or total cholesterol levels [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Yogurt Containing <b><i>Lactobacillus gasseri</i></b> Mitigates Aspirin-Induced Small Bowel Injuries: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Suzuki

Masui²,

Nakamura

et al. 2017

Digestion

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Background: Although there is evidence about the beneficial effects of probiotics, their effects on aspirin-induced small bowel injuries have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri OLL2716 (LG) on aspirin-induced small intestinal lesions, such as ulcers, erosions, reddened lesions, and bleeding. Summary: This study enrolled 64 patients who received aspirin for more than 1 month and provided written informed consent to be part of the study. The patients received 112 ml of yogurt containing LG or placebo twice daily for 6 weeks. Small bowel injuries were evaluated by capsule endoscopy before and after consuming the yogurt. The effect of LG on patient symptoms was also assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires before and after 6 weeks of treatment. There was no significant difference in any baseline characteristics and the number of small bowel mucosal breaks between the 2 groups. In contrast with the placebo group, the LG group had significantly fewer small bowel mucosal breaks and reddened lesions after 6 weeks (p < 0.01). The FSSG and GSRS scores were also significantly improved in the LG group but not in the placebo group. Key Messages: This double-blind, placebo-controlled study found that LG may be useful in reducing aspirin-induced small bowel injuries and in mitigating gastrointestinal symptoms.

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Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

Cited by 251 publications

References 53 publications

Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review

Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Yogurt Containing <b><i>Lactobacillus gasseri</i></b> Mitigates Aspirin-Induced Small Bowel Injuries: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

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