Pancreaticobiliary Maljunctions in European Patients with Bile Duct Cysts: Results of the Multicenter Study of the French Surgical Association (AFC)

Ragot, Emilia; Mabrut, Jean‐Yves; Ouaïssi, Mehdi; Sauvanet, Alain; Dokmak, Safi; Nuzzo, Gennaro; Halkic, Nermin; Dubois, R.; Létoublon, Christian; Cherqui, Daniel; Azoulay, Daniel; Irtan, Sabine; Boudjéma, Karim; Pruvot, François‐René; Gigot, Jean‐François; Kianmanesh, Réza

doi:10.1007/s00268-016-3684-x

Cited by 39 publications

(45 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for treatment, foreign authors believe cyst excision and Roux-en-Y biliary-jejunal anastomosis is the procedure of choice, offering the best results, a procedure we also used for our patient, with a postoperative evolution free of complications. Internal drainage of the cyst (cysto-duodenal anastomosis) was used in the past, but this procedure resulted in high morbidity rates due to potential complications (stenosis, biliary stasis, biliary lithi-asis, cholangitis), as well as due to the high risk of incidence of bile duct carcinoma (7).…”

Section: Discussionmentioning

confidence: 99%

Congenital choledochal cyst in a toddler – case report and literature review

Diaconescu¹,

Pharmacy²,

Strat³

et al. 2019

Ro J Pediatr

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital choledochal cyst in a toddler – case report and literature review

Diaconescu¹,

Pharmacy²,

Strat³

et al. 2019

Ro J Pediatr

View full text Add to dashboard Cite

show abstract

“…În ceea ce priveşte tratamentul, autorii străini consideră că excizia chistului şi anastomoza biliojejunală cu ansă în "Y" à la Roux reprezintă procedura de elecţie oferind cele mai bune rezultate, procedeu aplicat şi pacientului nostru, cu evoluţie postoperatorie fără complicaţii. În trecut se utiliza drenajul intern al chistului (chistoduodenoanastomoza) care însă genera o rată înaltă de morbiditate prin prisma posibilelor complicaţii (stenoză, stază biliară, litiază biliară, colangită) dar şi prin riscul ridicat de apariţie al carcinomului de cale biliară (7).…”

Section: Discuţiiunclassified

Chist Congenital De Coledoc La Un Sugar – Caz Clinic Şi Review De Literatură

Diaconescu¹,

Strat²,

Nichita³

et al. 2019

Ro J Pediatr.

View full text Add to dashboard Cite

show abstract

“…A critical complication of PBM is biliary malignancy. Although both gallbladder cancers and cholangiocarcinomas develop in patients with PBM, the former more commonly occurs in patients with isolated PBM …”

Section: Introductionmentioning

confidence: 99%

IL‐33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction

et al. 2019

View full text Add to dashboard Cite

Histopathology 75, 365-375. https://doi.org/10.1111/his.13863 IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunctionAims: To investigate whether genetic or inflammatory pro-oncogenic factors are relevant to the increased risk of gallbladder cancers in patients with pancreaticobiliary maljunction (PBM). Methods and results: Mutations in KRAS exon 2 were examined by a highly sensitive, droplet digital PCR platform using surgically resected specimens of PBM-associated (n = 31) and non-associated gallbladder cancers (n = 49). The tissue expression of IL-6 and IL-33, which are suspected to promote biliary carcinogenesis, was analysed by quantitative real-time PCR and in-situ hybridisation. The incidence of KRAS mutations was similarly low in PBM-associated (five of 32 cases; 16%) and non-associated cancers (four of 49 cases; 8%) (P = 0.272). The tissue expression of IL-33 mRNA, but not IL-6 mRNA, was significantly higher in PBM-associated gallbladder cancers than in gallbladder cancers without PBM (P = 0.004). A similar degree of IL-33 overexpression was also observed in the background non-cancerous mucosa in cases of PBM-associated gallbladder cancers, and was significantly greater than that in PBM cases with cholecystitis alone (P < 0.001). The results of in-situ hybridisation indicated that the source of IL-33 production in PBM-associated carcinomas was the endothelium, cancer cells and non-neoplastic biliary epithelium. In a combined PBM-associated and non-associated cohort, IL-33 overexpression in gallbladder cancers correlated with less aggressive features (e.g. a lower pT stage and longer overall survival), similar to recently reported findings on large-duct cholangiocarcinomas. Conclusions: KRAS mutations do not appear to be associated with a high risk of malignancy in PBM, while IL-33 overexpression may provide a pro-oncogenic microenvironment in the gallbladder mucosa of patients with PBM.

show abstract

Pancreaticobiliary Maljunctions in European Patients with Bile Duct Cysts: Results of the Multicenter Study of the French Surgical Association (AFC)

Abstract: Characteristics of PBM associated with BDC in Western population are quite close to reported Eastern series. The results suggest considering both the intrabiliary value of amylase >8000 UI/L and a length of a common channel >8 mm as appropriate values for positive diagnosis of PBM.

Cited by 39 publications

References 32 publications

Congenital choledochal cyst in a toddler – case report and literature review

Congenital choledochal cyst in a toddler – case report and literature review

Chist Congenital De Coledoc La Un Sugar – Caz Clinic Şi Review De Literatură

IL‐33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction

Contact Info

Product

Resources

About