Pancreaticojejunal Anastomotic Leak after Pancreaticoduodenectomy—Multivariate Analysis of Perioperative Risk Factors

Yeh, Ta Sen; Jan, Yi Yin; Jeng, Long Bin; Hwang, Tsann Long; Wang, Chia Siu; Chen, Shin Cheh; Chao, Tung‐Ying; Chen, Miin Fu

doi:10.1006/jsre.1996.4974

Cited by 99 publications

(76 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a prospective study by Matsusue et al [20] , only age was found to be a significant factor influencing the rate of PF. Yeh et al [21] identified prolonged duration of untreated jaundice, decreased creatinine clearance and increased intraoperative blood loss as three independent risk factors for PF. Small pancreatic duct size and ampullary carcinoma were significantly related with PF in a report by van Berge Henegouwen et al [22] , but systematic investigation of these potential risk factors is lacking and several of them may be interdependent.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is useful to identify risk factors for PF. Several factors including age, gender, jaundice, pancreatic texture, pathology, pancreatic duct size, intraoperative blood loss, operative time, anastomotic technique and pancreatic duct stent have been described [18,[20][21][22][23] . In a prospective study by Matsusue et al [20] , only age was found to be a significant factor influencing the rate of PF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pancreatic Fistula after Pancreaticoduodenectomy: Diagnosed according to International Study Group Pancreatic Fistula (ISGPF) Definition

2007

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pancreatic Fistula after Pancreaticoduodenectomy: Diagnosed according to International Study Group Pancreatic Fistula (ISGPF) Definition

2007

View full text Add to dashboard Cite

“…In a study of Marcus et al [17], male sex was found to be a significant factor predisposing pancreatic fistula. A recent study from Yeh et al [18], identified jaundice, creatinine clearance abnormality, and intraoperative blood loss as significant risk factors for leakage. Matsusue et al [19], found that One of the most common morbidities after PD is delayed gastric emptying with rates of 15-40% [20][21].…”

Section: Discussionmentioning

confidence: 99%

Analysis of procedure-related complications after pancreatodoudenectomy

et al. 2010

View full text Add to dashboard Cite

Purpose To analyze the procedure-related complications after pancreaticoduodenctomy (PD) and their risk factors.Methods One hundred twenty-six patients underwent pancreatoduodenectomy for diseases at region of pancreatic head were reviewed retrospectively. ResultsThe overall surgical morbidity was 40.5% (51/126). Ten (7.9%) of 51 patients were identified as having pancreatic leakage, others included delayed gastric emptying (8.7%, 11), abdominal infection and abscess (7.9%, 10), abdominal bleeding (5.6%, 7), wound infection (4.8%, 6), wound dehiscence (2.4%, 3), biliary fistula (1.6%, 2) and operative death (1.6%, 2). Other postoperative complications were lung inflammation (3.9%, 5) and newly developed diabetes mellitus (2.3%, 3). Age (>60 years), coexisting diabetes mellitus, small main pancreatic duct (≤0.5 cm), and surgeon's experience (<10 patients within 5 years) were demonstrated to be independent risk factors by both univariate and multivariate analysis (p < 0.01).Conclusions Old patients with coexisting diabetes mellitus and small main pancreatic duct undergo pancreatoduodenectomy by a less experienced surgeon may be at high risk of procedure-related complications.

show abstract

“…Using multivariate analysis, data from the literature identified BMI [40,41], diabetes [42,43], intraoperative blood loss [44], operative time [45], soft pancreatic texture [46], small Wirsung duct diameter [47] and stapled closure of the remnant pancreatic stump [43,45] as risk factors for postoperative pancreatic fistulae after standard pancreatic resections. A recent study used multivariate analysis to show that BMI ≥30 and age ≥40 years were risk factors for postoperative complications after CP [26].…”

Section: Discussionmentioning

confidence: 99%

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

et al. 2012

View full text Add to dashboard Cite

Background/Aim: The aim of the present study is to compare the postoperative and long-term outcomes of central pancreatectomy (CP) and spleen-preserving distal pancreatectomy (SPDP). Methods: Clinical, pathological and long-term data were compared between 22 patients who underwent CP and 25 patients who underwent SPDP (2002–2012). Results: The median length of resected pancreas was 8.5 cm in the SPDP group and 5 cm in the CP group (p < 0.001). The median estimated blood loss was significantly lower in the CP group (p = 0.019). Morbidity was 50% for CPs and 40% for SPDPs (p = 0.564). The rate of pancreatic fistulae was 36% for CPs and 40% for SPDPs (p = 0.530). The rate of new-onset diabetes was nil in the successful CP group and 16% in the SPDP group (p = 0.111). Conclusion: Morbidity and pancreatic fistula rates are not higher after CP when compared to SPDP. The loss of normal pancreatic tissue is significantly lower for CP, and thus there is potentially better preservation of the pancreatic endocrine functions. CP should be considered only in selected cases when preservation of the pancreas is of utmost importance, especially for lesions situated at the level of the pancreatic neck.

show abstract

Pancreaticojejunal Anastomotic Leak after Pancreaticoduodenectomy—Multivariate Analysis of Perioperative Risk Factors

Cited by 99 publications

References 4 publications

Pancreatic Fistula after Pancreaticoduodenectomy: Diagnosed according to International Study Group Pancreatic Fistula (ISGPF) Definition

Pancreatic Fistula after Pancreaticoduodenectomy: Diagnosed according to International Study Group Pancreatic Fistula (ISGPF) Definition

Analysis of procedure-related complications after pancreatodoudenectomy

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

Contact Info

Product

Resources

About