Pancreatitis associated with pleural-mediastinal pseudocyst, panniculitis and polyarthritis

Abstract

We describe two patients with pancreatitis. One patient had acute pancreatitis of biliary origin and presented with small joint polyarthritis and panniculitis lesions. The other patient was originally hospitalised for dyspnoea with bilateral pleural effusion, and subsequently developed migratory polyarthritis. During his hospital stay he developed panniculitis lesions and a monoclonal IgG disorder of unknown significance. Very few patients with pancreatitis develop polyarthritis and panniculitis. The appearance of pseudocysts in the pleural and mediastinal cavity in the course of pancreatitis is an infrequent complication.

Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs

“…The pathogenesis of the selective fat necrosis associated with these cases has not been completely determined. It is generally agreed that there is a massive release of pancreatic enzymes into the bloodstream, giving rise to necrosis and hydrolysis of adipocytes with secondary inflammation (Francombe and others 1995, Lopez and others 1998). This is supported by a case of chronic pancreatitis in which resolution of panniculitis occurred after placement of a pancreatic duct stent (Lambiase and others 1996).…”

Metabolic panniculitis: alpha-1 antitrypsin deficiency panniculitis and pancreatic panniculitis

“…Panniculitis develops in 2–3% of patients with pancreatic disease (38), most commonly those with acute or chronic pancreatitis usually due to alcohol abuse (35,39–41), cholelithiasis (42,43), and pancreatic calculi (44,45). Panniculitis has been documented with carcinoma of the pancreas, most commonly acinar (46–49), but neuroendocrine (50–52) and acinar cell cystadenocarcinoma (37) have also been reported.…”

“…Panniculitis has been documented with carcinoma of the pancreas, most commonly acinar (46–49), but neuroendocrine (50–52) and acinar cell cystadenocarcinoma (37) have also been reported. Less frequently, pancreatic panniculitis has been associated with pancreatic pseudocyts (45), congenital anomalies (53), lupus pancreatitis (54), pancreatitis following renal (55), and pancreas‐renal transplant (56), and after endoscopic retrograde pancreatography with sphincterotomy (57). Pancreatic panniculitis has also been documented in a child with nephrotic syndrome (hypertriglyceridemia → pancreatitis) (58).…”

Pancreatic Panniculitis Caused by l‐Asparaginase Induced Acute Pancreatitis in a Child with Acute Lymphoblastic Leukemia

“…The most frequent locations are the ankles and knees, although other areas have also been described including the thighs, buttocks, calves, arms, and abdominal wall (8). An associated arthritis and polyserositis may be present (16,17).…”