Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus

Wellmann, Klaus F.; Volk, Bruno W.

doi:10.1007/978-1-4684-2325-9_12

Cited by 4 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three dogs (nos.9, 10, 12) are still alive and non-diabetic after 4 years. In human chronic pancreatitis [22] or in the obstruction of pancreatic ducts by considerable fibrosis and destruction of the exocrine canals, in general diabetes develops after several years evolution [20,22], although no correlation exists between the intensity of pancreatic fibrosis and the development of diabetes, nor between the intensity of diabetes and the severity of exocrine and endocrine lesions [23]. In our dogs, the persistence of endocrine islets appeared to be sufficient to prevent the development of diabetes, but the disease can appear suddenly and evolve rapidly, in as little as I month as in dog no.…”

Section: Discussionmentioning

confidence: 99%

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation

et al. 1983

View full text Add to dashboard Cite

Summary. The injection of neoprene into the pancreatic ducts of dogs has been used to destroy exocrine function prior to pancreatic transplantation, The subsequent histological changes and the evolution of lesions over a period of 3 36 months are described. Animals were sacrified or biopsied at various intervals (3, 15 and 36 months) and the pancreases showed the disappearance of exocrine acini and changes of chronic pancreatitis. An immunoperoxidase procedure with insulin, glucagon, somatostatin and pancreatic polypeptide antisera was used to show the persistence of pancreatic endocrine cells. After the injections, sclerosis progressively increased and secondary lesions of the islets were seen, although functional islets persisted. This technique was then applied to pancreas transplantation in man. Eight transplants from seven diabetic patients were available for examination. In four cases, there were early technical failures, but four pancreatic transplants continued to function for 28 889 days until suppuration destroyed one of the grafts and the three other patients died. The persistence of endocrine cells in sclerotic tissue was observed in histological and immunopathological examinations.Key words: Pancreas, transplantation, injection of neoprene, diabetes, dog.The degenerative complications caused by microangiopathy still remain a major problem in diabetic patients. New techniques which have been developed over the past few years in an attempt to slow the evolution of diabetic complications include electromechanical or biological artificial pancreases, implantation of adult or fetal endocrine islets and segmental pancreatic transplants [1]. The technical problems involved, however, have not yet been resolved completely [2][3][4][5]. Pancreatic transplants involve technical problems due, in part, to the need for the suppression or diversion of pancreatic exocrine secretion. Numerous methods have been used [6][7][8][9] but none of these is perfectly satisfactory [1,2]. We have used a technique (initially in dogs, then in man), in which suppression of pancreatic exocrine function is obtained by the injection of neoprene, a substance which rapidly solidifies in the pancreatic ducts. Materials and Methods DogsInjection Technique: Neoprene 671 (Safic Alcan, Puteaux, France) is a low viscosity, liquid rubber (70 units) of pH 12.4. Upon contact with the more acidic pancreatic juice (pH 8.9), this product is polymerised and precipitated. The surgical technique used [10, 11] was as follows: the main pancreatic duct was isolated in the vicinity of the duodenum and a polyethylene catheter (16 or 18 gauge) was inserted and introduced for several millimetres. Following aspiration of pancreatic juice, 1-6 ml pure neoprene were injected in situ followed by 0.2 ml acetic acid (180 retool/l) to accelerate polymerization. This produced a solid neoprene cast, which filled the major ducts and their radicles.In this study, 17 mongrel dogs were used. Two sets of experiments were carried out: group l=five animals received an inj...

show abstract

Section: Discussionmentioning

confidence: 99%

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation

et al. 1983

View full text Add to dashboard Cite

show abstract

“…Diabetes secondary to chronic pancreatitis has certain characteristic clinical features which are different from the average case of diabetes mellitus (For references, see Wellman and Volk, 1977). It occurs at a relatively early stage of life with an insidious onset, followed by slow progression.…”

Section: Discussionmentioning

confidence: 99%

“…CCP, in genearl, is rare and seems to be associated with alcoholism, malnutrition, biliary tract diseases and hyperparathyroidism (For references, see Wellman and Volk, 1977).…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus secondary to idiopathic chronic calcifying pancreatitis in an adolescent woman.

et al. 1983

View full text Add to dashboard Cite

Is Glucose Intolerance after Pancreatitis Related to Pancreatic Tissue Damage?

Seligson

Cho

Nygren

et al. 1983

Journal of Internal Medicine

View full text Add to dashboard Cite

Endoscopic retrograde pancreatography (ERP) was performed in 48 patients who had been hospitalized for pancreatitis. The fmdings were related to results of oral glucose tolerance tests. Patients with gross changes at J3RP tended to have latent or manifest diabetes. In patients with latent or manifest diabetes, the increase in C-peptide after oral glucose was lower than in healthy subjects, while iosulin sensitivity, estimated with euglycemic insulin clamp technique, was within the same range as in healthy subjects. It is concluded that gross changes of the pancreatic ducts after pancreatitis are often accompanied by widespread tissue damage leading to deficient B-cell function and decreased glucose tolerance.S-ALAT were elevated in 2 patients. S-ALP was increased in 6 patients (range 4.02-6.56, normal range 1.0-3.5 &at/]), 4 of whom had a stricture of the common bile duct. Two patients had elevated bilirubin values (26 and 46 pmol/l, normal range 4-21).Abbreviations: ERP = endoscopic retrograde pancreatography, OGTT = oral glucose tolerance test.

show abstract

Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus

Cited by 4 publications

References 44 publications

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation

Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation

Diabetes mellitus secondary to idiopathic chronic calcifying pancreatitis in an adolescent woman.

Is Glucose Intolerance after Pancreatitis Related to Pancreatic Tissue Damage?

Contact Info

Product

Resources

About