Pancreatitis with normal lipase and amylase in setting of end-stage renal disease

Sharma, Abha; Masood, Umair; Khan, Babar; Chawla, Kunal; Manocha, Divey

doi:10.1016/j.ajem.2017.07.014

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…The current study has some limitations. Specifically, this study is limited by not having a medication history [22,23], human immunodeficiency virus history [24], or alcohol use history [25], which can all contribute to elevated pancreatic enzyme levels. Additionally, our patients were not screened for SPINK1 and PRSS1 mutations, which may have an effect on amylase and lipase levels, though Gullo did not show any significance for these mutations [6].…”

Section: Discussionmentioning

confidence: 99%

The Utility of Endoscopic Ultrasound in Patients with Isolated Elevations in Serum Amylase and/or Lipase

et al. 2019

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Background/Aims The aim of this study was to describe the diagnostic yield of endoscopic ultrasound (EUS) in patients with isolated elevated levels of amylase and/or lipase. Methods A retrospective chart review was conducted at a large academic medical center from 2000 to 2016. Patients were selected based on having elevated amylase, lipase, or both, but without a diagnosis of pancreatitis or known pancreatobiliary disease. Patients were excluded if they had abnormal liver function tests or abnormal imaging of the pancreas. Results Of 299 EUS procedures performed, 38 met inclusion criteria. Symptoms were present in 31 patients, most frequently abdominal pain (87%). In 20 patients (53%), initial EUS most commonly found chronic pancreatitis ( n =7; 18%), sludge (5; 13%), or new diagnosis of pancreas divisum (3; 8%). In the asymptomatic patients (7), 3 had a finding on EUS, most importantly sludge (2), stone (1), and pancreas divisum (1). No patients were diagnosed with a mass or pancreatic cyst. During the follow up period, 6 patients (22%) had cholecystectomy. Conclusions In our study of patients with isolated elevations in amylase and/or lipase without acute pancreatitis who underwent EUS, approximately 50% had a pancreatobiliary finding, most commonly chronic pancreatitis or biliary sludge.

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Section: Discussionmentioning

confidence: 99%

The Utility of Endoscopic Ultrasound in Patients with Isolated Elevations in Serum Amylase and/or Lipase

et al. 2019

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“…On review of literature, twenty-three published cases of AP with normal lipase levels were found available and can be accessed through PubMed search online. [4][5][6][7][8][9][10][11][12][13] All retrievable information related to demographic profile, aetiologies, outcomes, etc. are presented in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, a few cases of AP with normal lipase levels have also been reported. [4][5][6][7][8][9][10][11][12][13] We report a similar case of AP, where serum lipase levels surprisingly remained normal throughout the course of the disease. Moreover, a brief review of all such case reports published till 2021 is presented here in a tabulated form (Table 1 and 2, and Figure 1,2,3).…”

Section: Introductionmentioning

confidence: 99%

Normal lipase acute pancreatitis: A case report and brief review of literature

2022

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Acute pancreatitis is a common presentation in Emergency Department. Elevated amylase and lipase level are one of the three important criteria to diagnose acute pancreatitis. Out of amylase and lipase, the latter is considered more specific for acute pancreatitis. We report a case of acute pancreatitis with a normal lipase level. On review of published literature on acute pancreatitis with normal lipase levels, 23 such case reports were retrieved. A brief review of all these cases including the case presented here had unknown etiology in 50% of cases followed by alcohol and gall stone. Pain abdomen was the commonest presentation followed by vomiting. The normal discharge could be done in 71% of cases and 17% of patients were non-survivors. Hence, normal lipase cannot rule out acute pancreatitis on its own. A typical presentation of acute pancreatitis needs radiological work up like an Ultrasound abdomen or CT scan with IV contrast (if not contraindicated) before refuting its possibility.

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Serum lipase as a biomarker for early prediction and diagnosis of post-endoscopic retrograde cholangiopancreatography pancreatitis

Wan

Deng

2019

Ir J Med Sci

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Pancreatitis with normal lipase and amylase in setting of end-stage renal disease

Cited by 3 publications

References 3 publications

The Utility of Endoscopic Ultrasound in Patients with Isolated Elevations in Serum Amylase and/or Lipase

The Utility of Endoscopic Ultrasound in Patients with Isolated Elevations in Serum Amylase and/or Lipase

Normal lipase acute pancreatitis: A case report and brief review of literature

Serum lipase as a biomarker for early prediction and diagnosis of post-endoscopic retrograde cholangiopancreatography pancreatitis

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