Pancuronium Allergy: A Case Report

Abstract

A case of anaphylactic shock to pancuronium bromide is described in which a type I immunological reaction occurred. A 33-yr-old male anaesthetist, with no family or personal history of allergy, collapsed soon after induction of anaesthesia. The drugs used included fentanyl, droperidol, thiopentone and pancuronium. Diffuse erythema occurred, with probable cardiac arrest. The patient was treated with cardiac massage, sympathomimetics and cortisone, and made a complete recovery. Examination (skin tests, passive transfer according to Prausnitz and Küstner, in vitro lymphocyte transformation test, total IgE assay) revealed that the allergic reaction was to pancuronium bromide.

Anaphylactic reactions during induction of anaesthesia using rocuronium for muscle relaxation: A report including 3 cases

“…The case reports illustrate that serious drug reactions associated with the use of rocuronium may appear clinically in two very different ways: in cases 1 and 2 circulatory collapse was the main clinical sign; in case 3 bronchospasm was the dominant sign, without concomittent hypotension. Similar clinical scenarios are described in the literature in conjunction with the use of all other available nondepolarizing muscle relaxants, such as vecuronium ( 9–11), pancuronium ( 12, 13), atracurium ( 14–16), cisatracurium ( 17, 18), and mivacurium ( 19).…”

Volume 100: Case reports: should they be confined to the dustbin?

“…7 -12 A good example is the very rare but potentially life-threatening anaphylaxis to pancuronium. 11 Such reports have been the original source of an introduction to a new technique, 13 and a reminder of an established but often forgotten way of managing a particular clinical problem. 14 Some case reports have explored interesting physiological changes, which have subsequently been utilized in clinical practice.…”