Pancytopenia After Allogeneic Bone Marrow Transplant Due to Copper Deficiency

Abstract

Pancytopenia occurring 1 year or later after allogeneic bone marrow transplantation typically prompts a primary consideration for relapse. We present the case of a 15-year old-girl who underwent transplantation for therapy-related myelodysplasia secondary to Ewing sarcoma treatment who developed pancytopenia with myelodysplasia 1 year after transplant due to copper deficiency. Copper deficiency is an important consideration in the evaluation of pancytopenia and myelodysplasia in pediatric patients.

Graft versus host disease after liver transplantation following radiotherapy for the treatment of hepatocellular carcinoma: A case report and literature review

“…Pancytopenia is more common in lt-GVHD than in GVHD patients after hematopoietic stem cell transplantation. [37][38][39][40] The reason is that the lymphocytes transferred from the donor liver attack and destroy the recipient's hematopoietic stem cells or use immunosuppressive drugs and viral, bacterial, and fungal infections. In addition, severe aplastic anemia can also occur several months after LT. [41][42][43] GVHD may also affect the lungs and brain, causing symptoms such as dyspnea, hallucinations, and disturbance of consciousness, but not established.…”