Pancytopenia in Lyme disease

Mehrzad, Raman; Bravoco, Joseph

doi:10.1136/bcr-2013-201079

Cited by 6 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, anemia was more likely regenerative either due to blood loss or hemolysis that could be attributed to the above reported mechanisms [40][41][42]. Additionally anemia was evidenced in studies in human [70] and dogs with B. burgdorferi infection [39].…”

Section: Discussionmentioning

confidence: 50%

Hematological Features in Sheep with IgG and IgM Antibodies against Borrelia burgdorferi sensu lato

et al. 2021

View full text Add to dashboard Cite

Exposure of sheep to Borreliaburgdorferi sensulato (s.I.) complex, the causative agent of Lyme borreliosis (LB), has been reported in tick-abundant areas worldwide, while no data have been reported in Greece. The aim of the study was to identify the hematological alterations in sheep with seropositivity against Borrelia burgdorferi (s.I.). Blood samples were obtained from 318 tick infested sheep for blood analysis and serological determination of IgG and IgM antibodies against B. burgdorferi by indirect immunofluorescence antibody (IFA) assay after exclusion of endo-ectoparasites and other tick-borne infections. A total number of 162 sheep met the inclusion criteria, allocated in four groups based on the presence or absence of IgG and/or IgM; sheep found negative for IgM and IgG (Group A), positive for IgM (Group B), positive for both IgM and IgG (Group C) and positive for IgG (Group D). Anemia, thrombocytopenia and normal or decreased leukocyte count, mainly due to lymphopenia were the main hematological features observed in seropositive sheep. The presence of these features raises the suspicion of Borrelia infection in tick infested sheep. The seropositivity of 23.58% in sheep raises concerns of Borrelia circulation, especially in rural areas and potential risk of transmission to humans.

show abstract

Section: Discussionmentioning

confidence: 50%

Hematological Features in Sheep with IgG and IgM Antibodies against Borrelia burgdorferi sensu lato

et al. 2021

View full text Add to dashboard Cite

show abstract

“…However, CD4% could be more indicative of patients’ responses to antibiotic treatment. T-cell lymphopenia can occur in patients with TBIs like acute Lyme disease [ 14 , 15 ]. CD3, CD8, and CD4 T cell lymphocytes are crucial in mounting an effective immune response against infections [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…The causative pathogens have multiple mechanisms to evade and dysregulate the host immune system [ 12 , 13 ], leading to decreased microbial clearance. Abnormal changes in lymphocyte subpopulations and clinical biomarkers have been associated with Lyme disease and other TBIs [ 14 , 15 , 16 , 17 , 18 , 19 ]. Laboratory markers can also narrow the differential diagnosis by ruling out conditions with clinical manifestations similar to Lyme disease.…”

Section: Introductionmentioning

confidence: 99%

Scrutinizing Clinical Biomarkers in a Large Cohort of Patients with Lyme Disease and Other Tick-Borne Infections

Xi,

Garg,

Lambert

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Standard clinical markers can improve tick-borne infection (TBI) diagnoses. We investigated immune and other clinical biomarkers in 110 patients clinically diagnosed with TBIs before (T0) and after antibiotic treatment (T2). At T0, both the initial observation group and patients without seroconversion for tick-borne pathogens exhibited notably low percentages and counts of CD3 percentage (CD3%), CD3+ cells, CD8+ suppressors, CD4 percentage (CD4%), and CD4+ helper cells, with the latter group showing reductions in CD3%, CD3+, and CD8+ counts in approximately 15-22% of cases. Following treatment at the T2 follow-up, patients typically experienced enhancements in their previously low CD3%, CD3+ counts, CD4%, and CD4+ counts; however, there was no notable progress in their low CD8+ counts, and a higher number of patients presented with insufficient transferrin levels. Moreover, among those with negative serology for tick-borne infections, there was an improvement in low CD3% and CD3+ counts, which was more pronounced in patients with deficient transferrin amounts. Among those with CD57+ (n = 37) and CD19+ (n = 101) lymphocyte analysis, 59.46% of patients had a low CD57+ count, 14.85% had a low CD19 count, and 36.63% had a low CD19 percentage (CD19%). Similar findings were observed concerning low CD57+, CD19+, and CD19% markers for negative TBI serology patients. Overall, this study demonstrates that routine standard clinical markers could assist in a TBI diagnosis.

show abstract

“…In general, pancytopenia is a rare manifestation of ehrlichiosis, [2,3] and pancytopenia has also been reported with other tick-borne illnesses like Lyme disease [8] and anaplasmosis [6,9]. Notably, co-infection with multiple tick-borne pathogens (e.g.…”

Section: Discussionmentioning

confidence: 99%

Fever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report

et al. 2021

View full text Add to dashboard Cite

Background Pancytopenia, fever, and elevated D-dimer are significant clinical findings. The differential diagnosis includes hematological malignancies, severe coronavirus disease 2019 (COVID-19), tick-borne illnesses, and other etiologies. Case presentation We report the case of a 95-year-old woman who presented with high fever (103.6 °F), pancytopenia, and markedly elevated D-dimer (32.21 mg/L; reference range ≤ 0.95 mg/L) in late-autumn during the COVID-19 pandemic at a large academic institution. After remaining persistently febrile, a peripheral blood smear was ordered and revealed parasites consistent with Ehrlichia spp. Doxycycline monotherapy led to symptomatic improvement and resolution of her pancytopenia. During her hospital stay, a computed tomography angiogram of the chest revealed pulmonary emboli, and esophagogastroduodenoscopy uncovered arteriovenous malformations. After appropriate treatment, she was discharged on hospital day 7 and has since done well. Conclusions Overall, our case offers a dramatic, unexpected presentation of ehrlichiosis in a nonagenarian. To our knowledge, this is the first report of concurrent ehrlichiosis and pulmonary embolus.

show abstract

Pancytopenia in Lyme disease

Cited by 6 publications

References 18 publications

Hematological Features in Sheep with IgG and IgM Antibodies against Borrelia burgdorferi sensu lato

Hematological Features in Sheep with IgG and IgM Antibodies against Borrelia burgdorferi sensu lato

Scrutinizing Clinical Biomarkers in a Large Cohort of Patients with Lyme Disease and Other Tick-Borne Infections

Fever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report

Contact Info

Product

Resources

About