In the current difficult economic and social situation in Romania and worldwide characterized by the health crisis caused by the evolutions of the SARS CoV-2 pandemic, the present study aims to highlight the amplitude to which the risk of occupational health and safety influences the continuity and sustainability of business in Romania. The research methodology adopted by the authors was based on the research highlighted in the specialized literature and by considering firstly the analysis of the results of the survey realized by applying a questionnaire to the employees from different fields of activity during the period February 29 - March 15, 2020. Secondly, the authors considered the analysis of the determinants of the risk of occupational health and safety at the level of the employers with an impact on the continuity and sustainability of the Romanian organizations, especially the businesses. The results of this research reveal how the working hypotheses in the second level of the analysis were confirmed or not regarding the impact of occupational and healthy risks on the sustainability of Romanian organizations under the SARS-COV-2 pandemic.