Pandemic (H1N1) 2009 Influenza in Pediatric Hematology/Oncology Units in Lebanon

Abstract

Immunocompromised children infected with pandemic 2009 influenza may respond very well when the diagnosis and treatment are rapid. However, on the basis of our experience, if the underlying disease is more severe (immunodeficiency with significant immunosuppressive treatment and induction of high-risk leukemia), the odds of mortality are likely greater.

Influenza A/H1N1 in Pediatric Oncology Patients

“…12 Thus, it is not surprising that in our study the outcome was generally favorable in both groups, as the underlying disease severity was similar. However, the underlying disease severity was found to be associated with prognosis.…”

“…[5][6][7] In another study, H1N1 infection in immunocompromised hosts was characterized by a clinical picture similar to that of immunocompetent patients but with a prolonged course and higher mortality. [9][10][11][12] The influenza A/H1N1 monovalent vaccines were well tolerated by young cancer patients during chemotherapy and achieved a protective immune response in most cases. [9][10][11][12] The influenza A/H1N1 monovalent vaccines were well tolerated by young cancer patients during chemotherapy and achieved a protective immune response in most cases.…”