Pandemic (H1N1) 2009 influenza — real threat or unjustified panic? The experience of one pediatric hematology-oncology center

Irga, Ninela; Osak, Marcelina; Jaworski, Radosław; Bronk, Marek; Kosiak, Wojciech; Adamkiewicz-Drożyńska, Elżbieta

doi:10.2478/s11536-011-0165-3

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…Patients with leukemia, a decreased albumin level, hypoxia at diagnosis, a respiratory co‐infection or receiving corticosteroids were at increased risk for LRI. Of these risk factors, lymphocytopenia and corticosteroid use have been related to severe influenza and poor outcomes in other studies of HM patients and HCT recipients . Authors also reported that hypoalbuminemia is a risk factor for pneumonia in a single‐center cohort of patients with hematological disease having influenza .…”

Section: Discussionmentioning

confidence: 91%

“…Influenza is increasingly recognized as a serious infection with fatal consequences in patients with HMs. However, only few studies focusing on influenza in cancer patients have been published . Most of these published studies included few patients with influenza during the H1N1 pandemic in the 2009 and 2010 influenza seasons, and few of them described the clinical presentations, risk factors, and outcomes during the pandemic and post‐pandemic seasons in this vulnerable patient population.…”

Section: Introductionmentioning

confidence: 99%

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Influenza in patients with hematological malignancies: Experience at two comprehensive cancer centers

Vilar‐Compte

Shah

Vanichanan

et al. 2017

Journal of Medical Virology

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The burden of influenza infections in patients with hematological malignancies (HMs) is not well defined. We describe the clinical presentation and associated outcomes of influenza at two comprehensive cancer centers (center 1 in the United States and center 2 in Mexico). Clinical and laboratory data on patients with HMs and influenza infection diagnosed from April 2009 to May 2014 at the two centers were reviewed retrospectively. A total of 190 patients were included, the majority were male (63%) with a median age of 49 years (range, 1‐88 years), and had active or refractory HMs (76%). Compared to center 1, patients in center 2 were significantly sicker (active cancer, decreased albumin levels, elevated creatinine levels, or hypoxia at influenza diagnosis) and experienced higher lower respiratory tract infection (LRI) rate (42% vs 7%; P < 0.001). In multivariable logistic regression analysis (odds ratio, 95% confidence interval), leukemia, (3.09, 1.23‐7.70), decreased albumin level (3.78, 1.55‐9.20), hypoxia at diagnosis (14.98, 3.30‐67.90), respiratory co‐infection (5.87, 1.65‐20.86), and corticosteroid use (2.71, 1.03‐7.15) were significantly associated with LRI; and elevated creatinine level (3.33, 1.05‐10.56), hypoxia at diagnosis (5.87, 1.12‐30.77), and respiratory co‐infection (6.30, 1.55‐25.67) were significantly associated with 60 day mortality in both centers. HM patients with influenza are at high risk for serious complications such as LRI and death, especially if they are immunosuppressed. Patients with respiratory symptoms should seek prompt medical care during influenza season.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Influenza in patients with hematological malignancies: Experience at two comprehensive cancer centers

Vilar‐Compte

Shah

Vanichanan

et al. 2017

Journal of Medical Virology

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“…Acute tamponade especially with bloody fluid always requires oncological diagnostics of potential neoplastic growth. Although the rapid disease course was due to viral infection, we could not exclude AH1N1 etiology of infection; no such test was done in our department before the AH1N1 pandemic in 2009 [7, 8]. …”

Section: Discussionmentioning

confidence: 99%

Bloody pericardial tamponade in a child treated for pneumonia mimiking a lung tumor and infiltration of the heart

Haponiuk¹,

Chojnicki²,

Jaworski³

et al. 2013

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We present the dramatic course of a female 5-year-old child with pneumonia and symptoms similar to local compression of the pericardium by a tumorous mass originating from the left lung. The child was treated with antibiotics for pneumonia with bilateral pleural effusions that required chest drainage. On the 10th day of therapy there was sudden anemia observed with the echocardiographic finding of acute cardiac tamponade. The child was referred for emergency life-saving surgical intervention. The chest was opened via a minimally invasive mini-incision in the area of the xiphoid process and bloody tension pericardial effusion was evacuated. The laboratory and histopathology investigations were not specific for neoplastic disease or tuberculosis infection. In the further observation the girl recovered and was discharged home two weeks after tamponade drainage. Fortunately our initial suspicion of neoplastic disease was not proved; nevertheless we would like to emphasize the need for oncologic vigilance in similar cases.

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Pandemic (H1N1) 2009 influenza — real threat or unjustified panic? The experience of one pediatric hematology-oncology center

Abstract: Abstract

Cited by 2 publications

References 14 publications

Influenza in patients with hematological malignancies: Experience at two comprehensive cancer centers

Influenza in patients with hematological malignancies: Experience at two comprehensive cancer centers

Bloody pericardial tamponade in a child treated for pneumonia mimiking a lung tumor and infiltration of the heart

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