Pandemic Influenza a (H1n1) 2009 Presenting as a Mild Disease in Children in a Croatian Clinical Centre

Čeljuska-Tošev, Elvira; Nikolić, Jadranka; Markotić, Filipa; Vukojević, Mladenka; Bebek-Ivanković, Helien; Kuzman, Ilija

doi:10.20471/acc.2019.58.03.04

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Another study provided no information regarding disease severity [26]. Last but not least, 20 studies failed to provide information on children with obesity and influenza infection [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. Finally, a total of 7 studies were included in the quantitative analysis [47][48][49][50][51][52][53].…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

et al. 2022

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Obesity has been recently identified as a predisposing factor for a worse prognosis in viral illnesses such as SARS-CoV-2; however, its role in children with influenza is not yet clarified. The current systematic review and meta-analysis aims to assess whether obesity is a risk factor for either hospitalization or a worse prognosis when hospitalized among children infected by influenza. We systematically searched the following databases using a structured algorithm: MEDLINE, Clinicaltrials. gov, and Cochrane Central Register of Controlled Trials (CENTRAL). Statistical meta-analysis was performed using the "meta" package in R software, and included studies were evaluated using the Newcastle-Ottawa scale. Among children with influenza, obesity increased the odds of hospitalization with a pooled OR of 1.89 (95% CI [1.23, 2.9], I 2 = 0, p = 0.003). When hospitalized, children with obesity were also more likely to have a worse outcome than their healthy-weight counterparts, with a pooled OR of 1.24 (95% Cl [1.02; 1.51], I 2 = 11, p = 0.03). In an effort to lower heterogeneity, a leave-one-out meta-analysis was conducted. Publication bias was assessed with the visual inspection of funnel plots and the trim-and-fill method. Certainty assessment was evaluated using the GRADE score.Conclusions: The findings of our meta-analysis suggest that obesity in children with influenza is associated with a worse prognosis, both hospitalization and ICU admission/death. What is Known:• Obesity has been identified as a risk factor for non-communicable as well as communicable diseases.• A previous meta-analysis failed to demonstrate a statistically significant association between obesity and influenza infection severity. What is New:• Children with high BMI and influenza infection are more likely to get hospitalized. • Pediatric inpatients with increased BMI and influenza infection may have a worse prognosis.

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Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

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“…Another study provided no information regarding disease severity [24]. Last but not least, 20 studies failed to provide information on children with obesity and in uenza infection [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

Section: Study Selection Study Characteristicsmentioning

confidence: 99%

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

Vitoratou

Milas

Korovessi

et al. 2022

Preprint

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Purpose Obesity has been recently identified as a predisposing factor for worse prognosis in viral illnesses such as SARS-CoV-2, however, its role in children with influenza is not yet clarified. The current systematic review and meta-analysis aims to assess whether obesity is a risk factor for either hospitalization or worse prognosis when hospitalized among children infected by influenza. Methods We systematically searched the following databases: MEDLINE, Clinicaltrials.gov, and Cochrane Central Register of Controlled Trials (CENTRAL) using a structured algorithm. Statistical meta-analysis was performed using the ‘meta’ package in R software and included studies were evaluated using the Newcastle-Ottawa scale. ResultsAmong children with influenza, obesity increased the odds of hospitalization with a pooled OR of 1.89 (95% CI [1.23, 2.9], I2=0, p=0.003). When hospitalized, children with obesity were also more likely to have a worse outcome than their healthy-weight counterparts, with a pooled OR of 1.24 (95% Cl [1.02;1.51], I2=11, p=0.03). In an effort to lower heterogeneity Leave-one-out meta-analysis was conducted. Publication bias was assessed with the visual inspection of funnel plots and the trim-and-fill method. Certainty assessment was evaluated using the GRADE score. ConclusionsThe findings of our meta-analysis suggest that obesity in children with influenza is associated with a worse prognosis; both hospitalization and ICU admission/death. //

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Pandemic Influenza a (H1n1) 2009 Presenting as a Mild Disease in Children in a Croatian Clinical Centre

Cited by 2 publications

References 26 publications

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

Obesity as a risk factor for severe influenza infection in children and adolescents: a systematic review and meta-analysis

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