Panel of Oxidative Stress and Inflammatory Biomarkers in ALS: A Pilot Study

Blasco, Hélène; Garçon, Guillaume; Patin, Franck; Veyrat-Durebex, Charlotte; Boyer, Judith; Devos, David; Vourc’h, Patrick; Andres, Christian R.; Corcia, Philippe

doi:10.1017/cjn.2016.284

Cited by 111 publications

(92 citation statements)

References 33 publications

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“…Several studies have showed the usefulness of oxidative stress biomarkers that were measured in the blood, plasma, serum, urine, or CSF in the diagnosis of NDDs [77,78,[111][112][113][114][115]. However, so far, scarce literature data describe their diagnostic value in saliva.…”

Section: Summary and Perspectivementioning

confidence: 99%

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Maciejczyk

Gerreth

2020

JCM

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Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, are disorders, which cause irreversible and progressive deterioration of the central nervous system. The pathophysiology of NDDs is still not fully explained; nevertheless, oxidative stress is considered as a critical mediator of cerebral degeneration, brain inflammation, as well as neuronal apoptosis. Therefore, it is not surprising that redox biomarkers are increasingly used in the diagnosis of neurodegenerative diseases. As saliva is a very easy to obtain bioliquid, it seems promising to use this biomaterial in the diagnosis of NDDs. Saliva collection is easy, cheap, stress-free, and non-infectious, and it does not require the help of a specialised medical personnel. Additionally, the concentrations of many salivary redox biomarkers correlate with their content in blood serum as well as the degree of disease progression, which makes them non-invasive indicators of NDDs. This paper reviews the latest knowledge concerning the use of salivary redox biomarkers in the diagnosis and prognosis of selected neurodegenerative diseases.

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Section: Summary and Perspectivementioning

confidence: 99%

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Maciejczyk

Gerreth

2020

JCM

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“…Markers for OS have been determined in the cerebrospinal fluid (CSF), tissues, blood and urine of patients with ALS (Blasco et al, 2017). After postmortem analysis of neuronal tissues in sALS and fALS patients, an increase of OS biomarkers was noted in proteins, lipids and DNA (Beal, 2002;Agar and Durham, 2003;Kim et al, 2003;Turner et al, 2013;Bozzo et al, 2016).…”

Section: High Levels Of Certain Types Of Ros (H 2 O 2 and O •−mentioning

confidence: 99%

“…The evaluation of GPx activity, glutathione reductase (GR), SOD, total serum antioxidant status (TAS), MDA and 8-OHdG in ALS patients, found a significant decrease in TAS levels and an increase of 8-OHdG and MDA levels, together with significantly higher oxidized/reduced glutathione (GSSG/GSH) ratio and IL-6 and IL-8 (Blasco et al, 2017).…”

Section: High Levels Of Certain Types Of Ros (H 2 O 2 and O •−mentioning

confidence: 99%

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

et al. 2020

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD +) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS.

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“…Mutant SOD1 leads to aggregation in motor neurons within the CNS [193]. Other causes include oxidative stress, neuroin lammation, glutamate excitotoxicity, changes in neuro ilaments, mitochondrial degeneration and damage, protein aggregation, apoptosis, and de iciencies in factors related to growth [46,[203][204][205]. Owing to the accumulation of dysfunctional mitochondria within the motor neurons impacted by the sporadic and genetic types of ALS, there is a clear indication that a failure to maintain healthy mitochondria exacerbates ALS [206,207].…”

Section: Als and Oxidative Stressmentioning

confidence: 99%

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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Panel of Oxidative Stress and Inflammatory Biomarkers in ALS: A Pilot Study

Abstract: We confirmed the systemic alteration of both the redox and the inflammation status in ALS patients, and we observed a link with some clinical parameters. These promising results encourage us to pursue this study with collection of combined oxidative stress and inflammatory markers.

Cited by 111 publications

References 33 publications

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Salivary Redox Biomarkers in Selected Neurodegenerative Diseases

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

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