Panel studies of air pollution in patients with COPD: Systematic review and meta-analysis

Bloemsma, Lizan D.; Hoek, Gerard; Smit, Lidwien A M

doi:10.1016/j.envres.2016.08.018

Cited by 95 publications

(60 citation statements)

References 58 publications

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“…Chronic obstructive pulmonary disease (COPD) is a progressing condition with accelerated lung function decline, which requires early recognition and treatment and is often associated with smoking, 1,2 air pollution, 3,4 and occupational exposure to noxious gases and particles in the workplace. 5 A recent comprehensive review on the occupational burden of respiratory disease concluded that every tenth COPD case may be attributed to hazardous occupations.…”

Section: Introductionmentioning

confidence: 99%

<p>Lifetime Occupational History, Respiratory Symptoms and Chronic Obstructive Pulmonary Disease: Results from a Population-Based Study</p>

Vinnikov¹,

Raushanova²,

Kyzayeva³

et al. 2019

COPD

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Purpose: To ascertain the effect of lifelong occupational history, ambient air pollution, and biochemically verified smoking status on chronic obstructive pulmonary disease (COPD) in a general population of one the largest cities in Central Asia, Almaty. Patients and methods: 1500 adults (median age 49, interquartile range (IQR) 28 years), 50% females, were randomly selected from a registry of enlisted population of a primary care facility in Almaty, Kazakhstan and they filled in the questionnaire on demographics, respiratory symptoms (CAT and mMRC), smoking status, verified by exhaled carbon monoxide, and detailed lifetime occupational history. COPD was defined as postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) below lower limit of normal (LLN) using Belintelmed MAS-2 spirometer (Belarus). Results: 230 (15%) subjects had CAT≥10; 136 (9%) participants had mMRC score ≥2. Greater CAT score was associated with age, smaller income, and less exercise, but not with smoking or living closer to a major road. 26% of the population was ever exposed to vapors, gases, dusts, and fumes (VGDF). In age group 40 years and above (N=1024), COPD was found in 57 participants (prevalence 5.6%), more in men (8.7% vs 3.4%). In the multivariate model adjusted for age, sex, ever-smoking, income, and exercise, any exposure to VGDF increased the odds of COPD (odds ratio (OR) 1.71; 95% confidence interval (CI) 1.03; 2.84), more in the highest exposure category (OR 2.36 (95% CI 1.20; 4.66)). Conclusion: Lifetime exposure to VGDF, found in ¼ of the general population, increased the odds of COPD independent of smoking by 71%.

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Section: Introductionmentioning

confidence: 99%

<p>Lifetime Occupational History, Respiratory Symptoms and Chronic Obstructive Pulmonary Disease: Results from a Population-Based Study</p>

Vinnikov¹,

Raushanova²,

Kyzayeva³

et al. 2019

COPD

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“…Since then, observational studies have accumulated evidence about the association between selected outdoor air pollutants and worsening of asthma symptoms [5, 6]. A recent meta-analysis of panel studies in COPD patients revealed that a10 μgPM 10 /m 3 increase in ambient levels had a small, but statistically significant impact on FEV1 and peak expiratory flow (PEF), but also showed significant heterogeneity across the included studies [7]. …”

Section: Introductionmentioning

confidence: 99%

Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults

et al. 2017

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BackgroundDaily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target.MethodsTo evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained annual lung function measurements from a routine worker health surveillance program not designed for research purposes. Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1), FEV1/FVC and Peak Expiratory flow (PEF) from a cohort of 2449 employees were associated with daily measurements of PM10, NO2 and ozone at a nearby monitoring station in the North of Belgium. Repeated measures were available for the period 2011–2015.ResultsThe mean (SD) PM10 concentration on the day of the lung function test was 24.9 (15.5) μg/m3. A 10 μg PM10/m3 increase on the day of the clinical examination was associated with a 18.9 ml lower FVC (95% CI: -27.5 to −10.3, p < 0.0001), 12.8 ml lower FEV1 (−19.1 to −6.5; p < 0.0001), and a 51.4 ml/s lower PEF (−75.0 to −27.0; p < 0.0001). The FEV1/FVC-ratio showed no associations. An increase of 10 μgNO2/m3 was associated with a reduction in PEF (−66.1 ml/s (−106.6 to −25.6; p < 0.001)) on the day of the examination.ConclusionsWe found negative associations between daily variations in ambient air pollution and FVC, FEV1 and PEF in healthy adults.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0271-z) contains supplementary material, which is available to authorized users.

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“…Although previous studies indicated that PM 2.5 is a significant environment trigger for acute exacerbation of COPD, and thus leading to increasing symptoms, emergency visits, hospital admissions and mortality [10–13]. A study conducted in China showed that 83% of the population lived in areas where PM 2.5 concentrations exceeded the Chinese Ambient Air Quality Standard of 35 μg/m 3 , premature mortalities attributed to PM 2.5 nationwide were 0.17 million for COPD [21].…”

Section: Discussionmentioning

confidence: 99%

“…The Global Burden of Disease study showed that COPD was the third leading cause of deaths in the world and ranked the ninth of global YLL in 2010 [9]. There is compelling evidence that short-term exposure to particulate matter is a risk factor for the development and exacerbation of COPD [10–13]. However, the availability of studies on the associations between ambient PM 2.5 and YLL of COPD is rare up to now, and the modifications of socioeconomic factors such as age, gender and marital status are unclear.…”

Section: Introductionmentioning

confidence: 99%

The short term burden of ambient fine particulate matter on chronic obstructive pulmonary disease in Ningbo, China

Huang

et al. 2017

Environ Health

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BackgroundNumerous studies have found associations between ambient fine particulate matter (PM2.5) and increased mortality risk. However, little evidence is available on associations between PM2.5 and years of life lost (YLL). We aimed to estimate the YLL due to chronic obstructive pulmonary disease (COPD) mortality related to ambient PM2.5 exposure.MethodsA time-series study was conducted based on the data on air pollutants, meteorological conditions and 18,472 registered COPD deaths in Ningbo, China, 2011–2015. The effects of PM2.5 on YLL and daily death of COPD were estimated, after controlling long term trend, meteorological index and other confounders.ResultsThe impact of PM2.5 on YLL due to COPD lasted for 5 days (lag 0–4). Per 10 μg/m3 increase in PM2.5 was associated with 0.91 (95%CI: 0.16, 1.66) years increase in YLL. The excess YLL of COPD mortality were 8206 years, and 0.38 day per person in Ningbo from 2011 to 2015. The exposure-response curve of PM2.5 and YLL due to COPD showed a non-linear pattern, with relatively steep at low levels and flattened out at higher exposures.. Furthermore, the effects were significantly higher in the elderly than those in the younger.ConclusionsOur findings explored burden of PM2.5 on YLL due to COPD and highlight the importance and urgency of ambient PM2.5 pollution control and protection of the vulnerable populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0253-1) contains supplementary material, which is available to authorized users.

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Panel studies of air pollution in patients with COPD: Systematic review and meta-analysis

Cited by 95 publications

References 58 publications

<p>Lifetime Occupational History, Respiratory Symptoms and Chronic Obstructive Pulmonary Disease: Results from a Population-Based Study</p>

<p>Lifetime Occupational History, Respiratory Symptoms and Chronic Obstructive Pulmonary Disease: Results from a Population-Based Study</p>

Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults

The short term burden of ambient fine particulate matter on chronic obstructive pulmonary disease in Ningbo, China

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