2012
DOI: 10.1128/jb.00183-12
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Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia

Abstract: Corynebacterium diphtheriae is one of the most prominent human pathogens and the causative agent of the communicable disease diphtheria. The genomes of 12 strains isolated from patients with classical diphtheria, endocarditis, and pneumonia were completely sequenced and annotated. Including the genome of C. diphtheriae NCTC 13129, we herewith present a comprehensive comparative analysis of 13 strains and the first characterization of the pangenome of the species … Show more

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Cited by 138 publications
(163 citation statements)
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“…However, frequencies of recombination can be variable between different strains of the same species (Sangal et al, 2010), which may reflect differences in strain propensities for acquiring foreign DNA that may result in variations in pathogenicity. For example, differences in the abilities of C. diphtheriae strains to form pili and interact with the host (Ott et al, 2010) have been linked with the horizontal acquisition of islands harbouring genes encoding subunits of adhesive pili (Trost et al, 2012). These observations potentially indicate that there are differences in recombination frequencies between C. diphtheriae strains.…”
Section: Introductionmentioning
confidence: 87%
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“…However, frequencies of recombination can be variable between different strains of the same species (Sangal et al, 2010), which may reflect differences in strain propensities for acquiring foreign DNA that may result in variations in pathogenicity. For example, differences in the abilities of C. diphtheriae strains to form pili and interact with the host (Ott et al, 2010) have been linked with the horizontal acquisition of islands harbouring genes encoding subunits of adhesive pili (Trost et al, 2012). These observations potentially indicate that there are differences in recombination frequencies between C. diphtheriae strains.…”
Section: Introductionmentioning
confidence: 87%
“…In addition to the 13 strains analysed by Trost et al (2012) (GenBank accession nos. BX248353, CP003206-17), genomes of two recently sequenced strains from the pre-vaccination era NCTC 3529 (Sangal et al, 2012b) and NCTC 5011 (Sangal et al, 2012a) (GenBank accession nos.…”
Section: Methodsmentioning
confidence: 99%
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