Panhypopituitarism due to Transection of the Pituitary Stalk Diagnosed Nine Years after Traumatic Brain Injury

Abstract

Traumatic brain injury is frequently involved in cases of hypopituitarism. We report a case of panhypopituitarism due to transection of the pituitary stalk that we diagnosed 9 years after the traumatic brain injury. If a patient develops unexplained or non-specific symptoms, the physician should consider the possibility of hypopituitarism.

Distinguishing between post-trauma pituitary stalk disruption and genetic pituitary stalk interruption syndrome – case presentation and literature overview

“…Hypoglycemia can also be caused by growth hormone deficiency and be accompanied with growth retardation worsened by central thyroid insufficiency and central hypogonadism resulting from gonadotropin deficiency. Our case in compliance with another current reports for PSTS typical is strict temporal relation of hormonal signs occurrence with head trauma, which caused pituitary stalk transaction, while in PSIS patients it depends upon severity of the developmental defect and progressive worsening of endocrine impairment throughout childhood and adolescence [39,48,49]. At diagnosis isolated growth hormone deficiency is diagnosed in 52% of the PSIS patients while CPHD in 48%, and after 12 years follow-up CPHD was confirmed in 83% patients [17].…”