Panic attacks after treatment with zuclopenthixol decanoate

Abstract

The association between neuroleptics and anxiety is unclear: neuroleptics have been used to treat anxiety though may also themselves be anxiogenic. We present the case of a man who developed new onset panic attacks after treatment with zuclopenthixol decanoate, a commonly administered depot antipsychotic. We review the literature on the association between antipsychotics and anxiety and present possible pathophysiological mechanisms.