Panic Attacks, Daily Life Ischemia, and Chest Pain in Postmenopausal Women

Smoller, Jordan W.; Pollack, Mark H.; Wassertheil‐Smoller, Sylvia; Brunner, Robert L.; Curb, David; Torner, James C.; Oberman, Albert; Hendrix, Susan L.; Hsia, Judith; Sheps, David S.

doi:10.1097/01.psy.0000244383.19453.c5

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Defective neuronal reuptake of noradrenaline might have a dual effect, sensitizing the heart in a way that leads to symptom development and potentially contributing to adverse cardiac events in patients with established PD (18). In addition to the association between PWD and PD, Smoller et al (27) indicate that anxiety and panic symptoms (and increased sympathetic autonomic regulation) may be associated with reduced heart rate variability, which, in turn, is associated with acute cardiac events and ventricular arrhythmias (8,28). Such abnormalities could trigger cardiac arrhythmias and coronary artery spasms and cause angina symptoms and ECG changes related to ischemia (21).…”

Section: Discussionmentioning

confidence: 99%

Association Between Panic Disorder and Risk of Atrial Fibrillation

Cheng

Leu

et al. 2013

Psychosomatic Medicine

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Section: Discussionmentioning

confidence: 99%

Association Between Panic Disorder and Risk of Atrial Fibrillation

Cheng

Leu

et al. 2013

Psychosomatic Medicine

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“…These two social-environmental exposures were measured at enrollment, concurrently with depressive symptoms. Stressful life events were assessed using a scale modified from the Almeida County Study 37,38 , which asked women to indicate whether they had experienced 11 different major losses or traumatic events in the past year (see Supplemental Materials for specific items). Items were summed to create a total count of the number of past-year stressors among those with complete data on all stressors (ranging from 0–11).…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study (Gwas) and Genome-Wide by Environment Interaction Study (Gweis) of Depressive Symptoms in African American and Hispanic/Latina Women

et al. 2016

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Background Genome-wide association studies (GWAS) have been unable to identify variants linked to depression. We hypothesized that examining depressive symptoms and considering gene-environment interaction (G×E) might improve efficiency for gene discovery. We therefore conducted a GWAS and genome-wide environment interaction study (GWEIS) of depressive symptoms. Methods Using data from the SHARe cohort of the Women’s Health Initiative, comprising African Americans (n=7179) and Hispanics/Latinas (n=3138), we examined genetic main effects and G×E with stressful life events and social support. We also conducted a heritability analysis using genome-wide complex trait analysis (GCTA). Replication was attempted in four independent cohorts. Results No SNPs achieved genome-wide significance for main effects in either discovery sample. The top signals in African Americans were rs73531535 (located 20kb from GPR139, p=5.75×10−8) and rs75407252 (intronic to CACNA2D3, p=6.99×10−7). In Hispanics/Latinas, the top signals were rs2532087 (located 27kb from CD38, p=2.44×10−7) and rs4542757 (intronic to DCC, p=7.31×10−7). In the GWEIS with stressful life events, one interaction signal was genome-wide significant in African Americans (rs4652467; p=4.10×10−10; located 14kb from CEP350). This interaction was not observed in a smaller replication cohort. Although heritability estimates for depressive symptoms and stressful life events were each less than 10%, they were strongly genetically correlated (rG=0.95), suggesting that common variation underlying depressive symptoms and stressful life event exposure, though modest on their own, were highly overlapping in this sample. Conclusions Our results underscore the need for larger samples, more GWEIS, and greater investigation into genetic and environmental determinants of depressive symptoms in minorities.

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“…Whether because of decreased heart rate variability, microvascular angina, or coronary artery disease, ischemia is believed to be the cause of chest pain during panic attacks. Smoller et al 22 found an association between panic attacks and both ischemic and nonischemic chest pain among women undergoing Holter monitoring. In fact, in a large managed care database, an association between diagnoses of panic disorder and coronary heart disease was found even after controlling for covariates (odds ratio = 1.87, 95% CI = 1.80 to 1.91).…”

mentioning

confidence: 99%

The Association Between Panic Disorder and Coronary Artery Disease Among Primary Care Patients Presenting With Chest Pain

Katerndahl

2008

Prim. Care Companion J. Clin. Psychiatry

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The association between panic disorder and CAD has several implications for primary care physicians managing patients with chest pain. When comorbid, the panic attacks may cause the patient with coronary disease to seek care but could also provoke a cardiac event. If one condition is recognized, a search for the other may be warranted because of the potential consequences if left undetected. The treatment approach to the panic disorder should be adjusted in the presence of comorbid CAD.

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Panic Attacks, Daily Life Ischemia, and Chest Pain in Postmenopausal Women

Cited by 8 publications

References 30 publications

Association Between Panic Disorder and Risk of Atrial Fibrillation

Association Between Panic Disorder and Risk of Atrial Fibrillation

Genome-Wide Association Study (Gwas) and Genome-Wide by Environment Interaction Study (Gweis) of Depressive Symptoms in African American and Hispanic/Latina Women

The Association Between Panic Disorder and Coronary Artery Disease Among Primary Care Patients Presenting With Chest Pain

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