Panik Bozukluğu Hastalarında Uykuda Kalp Hızı Değişkenliği

Yetkin, Sinan; Erdamar, Aykut; Yokuşoğlu, Mehmet; Özgen, Fuat; Aydin, Hamdullah

doi:10.4274/jtsm.05

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The aforementioned studies and our study may not be sufficient to provide information on sleep-wake and HRV difference. In a controlled polysomnographic study with panic disorder patients, no differences were detected between the patient group and the control group (26).…”

Section: Discussionmentioning

confidence: 86%

Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients

Durdu¹,

Kayıkçıoğlu²,

Pırıldar³

et al. 2018

Archives of Neuropsychiatry

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Introduction: It is well-known that autonomic function is impaired in panic disorder (PD). Heart rate variability (HRV) is a reliable and noninvasive method to evaluate autonomic functions. The aim of this study is to evaluate 24-hour heart rate variability (HRV) parameters in drug-free panic disorder patients. These results are compared with those obtained from healthy controls.Methods: Thirty-two (mean age 33.12±11.94 years, 20 female, 12 male) drug-free patients for at least 2 weeks, (for fluoksetin 3 weeks) diagnosed with panic disorder (PD) on the basis of DSM-IV criteria were included in the study. The control group comprised of 24 age and gender-matched healthy individuals (mean age 33.45±8.6 years, 17 female and 7 male) without any cardiac, endocrine (including diabetes), and neurological disease. Two groups were evaluated for any axis-I diagnosis with SCID-I. We used Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Panic Disorder Severity Scale (PDSS) and Anxiety Sensitivity Index-3 (ASI-3) tests in both groups. After the psychiatric evaluation 24 hours Holter ECG monitoring was performed in all participants for the determination of HRV including frequency and time domain parameters. Results:The time domain RMSSD and PNN50 values tended to be lower in panic patients but this difference did not reach significance (p=0.229, p=0.571). There was no significant difference in mean values for all time and frequency domain HRV measures over the total 24-hours recording between patients and controls. RMSSD, pNN50 and HF was increased to reflect the parasympathetic predominance in the sleeping period (p=0.0001) but there was no significant difference between groups. However LF value which showing sympathetic activity was increased significantly in healthy control and patients in the sleeping period (p=0.0001) but there was no significant difference between two groups (p=0.905). Correlation analysis in the panic disorder patients presented a negative correlation between disease age at onset HF value (p=0.004) and positive correlation between LF/HF value (p=0.007). When both smokers and non-smokers were compared in terms of HRV values, smoking significantly decreased HRV in both groups [SDNN (p=0,18)]. Conclusion:HRV parameters of panic disorder patients were not different from healthy controls. To better clarify the effects of panic disorder on HRV, factors effecting HRV should be minimized and more Holter ECG studies with longer records should be obtained to reflect the daily life activities.

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Section: Discussionmentioning

confidence: 86%

Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients

Durdu¹,

Kayıkçıoğlu²,

Pırıldar³

et al. 2018

Archives of Neuropsychiatry

View full text Add to dashboard Cite

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“…The increase in the HF could be depending on controlled respiration (30). The LF/HF ratio is the one of HRV feature that is a considerable indicator for the respiratory disorders (23,30,31). In this work, the power spectrum of HRV was computed and then the LF/HF ratio was calculated.…”

Section: Heart Rate Variability Analysismentioning

confidence: 99%

The Quantitative Analysis of Uvulopalatal Flap Surgery

Erdamar¹,

Bayrak²,

Fırat³

et al. 2017

jtsm

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Amaç: Bu çalışmada, uvulopalatal flap cerrahisinin kantitatif analizi için sinyal işleme tekniklerine dayanan yeni bir metodoloji önerilmektedir. Uvulopalatal flap ameliyatı ile ilgili klinik değerlendirme çalışmaları, doktorların muayenesine bağlı olmakla birlikte, hastanın subjektif geribildirimini de içermektedir. Kantitatif ve objektif değerlendirme çalışması literatürde halen eksiktir. Gereç ve Yöntem: Ameliyat öncesinde ve sonrasında 21 hastanın tüm gece uyku kayıtları analiz edilmiştir. Önerilen algoritma, iki bağımsız bölümden oluşmaktadır. Birinci bölümde, kalp hızı değişkenliği ve elektrokardiyogramın karmaşıklığı hesaplanmıştır. İkinci bölüm ise, elektroensefalogram alt bantlarının enerjilerinin hesaplanmasını içerir. Ardından, klinik ve deneysel parametreler arasındaki ilintinin belirlenmesi için istatistiksel yöntemler uygulanmıştır. Bulgular: Düşük frekans/yüksek frekans oranı ve beta dalgasının alt bant enerjisi, ameliyat sonrası delta uyku süresi düşük olan hastalar için anlamlıdır. Ayrıca, hem ameliyat sonrası delta uyku süresi hem de kan gazında ölçülen O 2 satürasyonu (SaO 2 ) parametresi yüksek olanlar için alfa ve beta dalgalarının ve teta dalgasının alt bant enerjileri anlamlıdır. Ameliyat sonrası solunum bozukluğu endeksi ve SaO 2 parametresi düşük olan hastalarda karmaşıklık anlamlıdır ve solunum bozukluğunun horlama indeksi ile ilintisi bulunmaktadır. Sonuç: Ameliyat öncesi ve sonrasındaki klinik bulgulara göre anlamlı olmayan solunum bozukluğu indeksinin karmaşıklık özelliği ile doğrudan ilişkili olduğu bulunmuştur. Bu çalışmanın en önemli sonucu, ameliyat öncesi karmaşıklık özelliğinin solunum bozukluğu ve horlama indeksi ile ilintili olmasıdır. Bu, karmaşıklık özelliğinin cerrahiden önce bir öngörü parametresi olabileceği anlamına gelmektedir. Anahtar Kelimeler: Uyku bozuklukları, obstrüktif uyku apnesi, uvulopalatal flap cerrahisi, karmaşıklık, Hjorth parametreleri Objective: In this work, a new methodology based on signal processing techniques for the quantitative analysis of uvulopalatal flap surgery is proposed. Clinical assessment studies of uvulopalatal flap surgery are based on not only the physician's examination, but also the patient's subjective feedback. Quantitative and objective evaluation studies are still lacking in the literature. Materials and Methods: Full night sleep records were analyzed for 21 patients before and after the surgery. The proposed algorithm consists of two independent parts. In the first part, the heart rate variability and complexity of the electrocardiogram were calculated. The second part includes calculating the electroencephalogram sub-band energy. Afterwards, the statistical methods were applied in order to determine the correlation of clinical and experimental parameters. Results: The low frequency/high frequency ratio and the sub-band energy of beta wave were significant for the patients having low postoperative delta sleep duration. Moreover, the sub-band energies of both alpha and beta waves, and theta wave were significant for the patients...

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Panik Bozukluğu Hastalarında Uykuda Kalp Hızı Değişkenliği

Cited by 2 publications

References 25 publications

Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients

Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients

The Quantitative Analysis of Uvulopalatal Flap Surgery

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