Pankreasgang-Okklusion durch Injektion einer schnellh�rtenden Aminos�urenl�sung

Abstract

The effect of the occlusion of the pancreatic duct system with a new alcoholic solution of amino acids has been studied in animal experiments. The solution becomes solid in the duct system, is microbiologically indifferent and becomes disintegrated within 11 days. This time, however, is sufficient to keep a high-grade atrophy of the exocrine parenchyma. With this method one doesn't risk the provocation of an acute pancreatitis. The development of fistulas following exploratory excision is prevented by the filling of the duct system. The solution could be qualified for a therapeutical acceleration of the "burning-out" of the chronic pancreatitis.

Influence of Pancreatic Duct Occlusion on Islet Hormones in Peripheral and Portal Plasma and in the Pancreas of the Mini-Pig

“…Occlusion of the pancreatic duct induces rapid atrophy of the exocrine parenchyma [15]. Accordingly, the median weight of the pancreas in Occ animals is only 3.6% of that in control animals.…”

“…The relative frequency of A-, B-, D-and PP-cells in the pancreatic islets was comparable in both control and Occ pigs. It is concluded that also in the pig pancreatic duct occlusion leads to atrophy of the exocrine pancreas, but leaves undisturbed basal blood glucose, insulin, glucagon and islet cells.Altough there are numerous reports on the general effects of pancreatic duct occlusion in humans and animals [1,10,15,22,24,27], little information is available on the long term influences of this technique on the en 1 Parts of this work have been published in abstract form (Eur. surg.…”

“…For instance, in insulin-dependent diabetes mellitus the exocrine pancreatic function is frequently impaired [7,14,15,16,24,37], and insulin regulates the synthesis of amylase at the level of transcription [31]. Conversely, a dependency of B-cell function on the exo crine pancreatic function has also been sup posed [2,8,19,28], The development of pan creatogenic diabetes is a characteristic feature of advanced chronic pancreatitis [34], and the administration of the bioactive carboxy terminal decapeptide of cholecystokinin has a trophic influence on the endocrine pan creas, in addition to its stimulating effect on pancreatic juice secretion [6], From these thoughts it appeared appropriate to study whether or not there are signs of impaired secretion of pancreatic islet hormones and the state of glucose regulation in a mamma lian species more closely related to man, after long-term duct occlusion and pancreas atro phy.…”

“…docrine system [5,18,20,36], The fate of the islet system is uncertain, because duct occlu sion induces atrophy of the exocrine paren chyma [10,11,15,16,24,36], Various inves tigations demonstrate an interrelationship of exocrine and endocrine pancreatic function. For instance, in insulin-dependent diabetes mellitus the exocrine pancreatic function is frequently impaired [7,14,15,16,24,37], and insulin regulates the synthesis of amylase at the level of transcription [31].…”

Pancreatic Fistulas in Pancreatic Transplantation

“…The properties of the quick-hardening, alcoholic amino acid solution (Ethibloc), are described in experimental studies by Gebhardt and Stolte [3,4]. The injection of this solution into the pancreatic duct leads to necrosis and in the further course to atrophy of the excretory parenchyma and the formation of an interstitial fibrosis, which starts on the 11th day after injection and is completed between the 50th and 60th day with a total extinction of the exocrine part of the parenchyma.…”