Pankrin

Lankisch, P. G.; Weber-Dany, Bettina; Doobe, Christian; Finger, Thorsten; Maisonneuve, Patrick; Lowenfels, Albert B.; Keim, Volker

doi:10.1097/01.mpa.0000218317.89706.6e

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…Enhanced TCA cycle activity is further supported by decreased levels of TCA cycle intermediates succinate and fumarate in Pt tissue, in broad agreement with previous reports indicating increases and decreases of TCA cycle intermediates at the beginning and end of the cycle, respectively (Sakai et al, 2012). Variations in creatine and creatinine may also be indicative of a disturbance in energy metabolism, although creatinine is also considered as a marker of pancreatic necrosis in acute Pt (Lankisch et al, 2010) . The decreases in membrane biosynthetic precursors (GPC, PC and PE) agree, in part, with lower GPC and/or PC levels reported for progressive chronic Pt in pigs (Sun et al, 2014) but appear to contradict increased choline compounds observed in Wistar rats affected by either acute or chronic Pt, as determined by high resolution magic angle spinning NMR, and interpreted as indicative of higher rates of cell proliferation (Ma et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model

Carneiro

Pinto

Serrao

et al. 2022

Front. Mol. Biosci.

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Untargeted Nuclear Magnetic Resonance (NMR) metabolomics of polar extracts from the pancreata of a caerulin-induced mouse model of pancreatitis (Pt) and of a transgenic mouse model of pancreatic cancer (PCa) were used to find metabolic markers of Pt and to characterize the metabolic changes accompanying PCa progression. Using multivariate analysis a 10-metabolite metabolic signature specific to Pt tissue was found to distinguish the benign condition from both normal tissue and precancerous tissue (low grade pancreatic intraepithelial neoplasia, PanIN, lesions). The mice pancreata showed significant changes in the progression from normal tissue, through low-grade and high-grade PanIN lesions to pancreatic ductal adenocarcinoma (PDA). These included increased lactate production, amino acid changes consistent with enhanced anaplerosis, decreased concentrations of intermediates in membrane biosynthesis (phosphocholine and phosphoethanolamine) and decreased glycosylated uridine phosphates, reflecting activation of the hexosamine biosynthesis pathway and protein glycosylation.

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Section: Discussionmentioning

confidence: 99%

Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model

Carneiro

Pinto

Serrao

et al. 2022

Front. Mol. Biosci.

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Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis

Rompianesi

Hann

Komolafe

et al. 2017

Cochrane Database of Systematic Reviews

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As about a quarter of people with acute pancreatitis fail to be diagnosed as having acute pancreatitis with the evaluated tests, one should have a low threshold to admit the patient and treat them for acute pancreatitis if the symptoms are suggestive of acute pancreatitis, even if these tests are normal. About 1 in 10 patients without acute pancreatitis may be wrongly diagnosed as having acute pancreatitis with these tests, therefore it is important to consider other conditions that require urgent surgical intervention, such as perforated viscus, even if these tests are abnormal.The diagnostic performance of these tests decreases even further with the progression of time, and one should have an even lower threshold to perform additional investigations if the symptoms are suggestive of acute pancreatitis.

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Akute Pankreatitis: Worauf es wirklich ankommt in der Diagnostik und der Therapie*

Lübbers¹,

Mahlke²,

Lankisch

2007

Med Klin

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KASUISTIKEine 72 Jahre alte Frau kommt mit seit 12 h bestehenden, zunehmend schwereren Oberbauchschmerzen in die Ambulanz. Sie klagt zusätzlich über Übelkeit und hat bereits mehrfach erbrochen. Bei der körperlichen Untersuchung besteht eine generelle Abwehrspannung im Abdomen. Die Amylase-und Lipasewerte sind deutlich, die Transaminasen massiv erhöht. Eine Ultraschalluntersuchung zeigt multiple kleine Steine in der Gallenblase, das Pankreas ist wegen Luftüberlagerung erst bei einer sofort durchgeführten kontrastmittelverstärkten Computertomographie darstellbar: eine nekrotisierende Pankreatitis, Balthazar-Score 8 Punkte.Die Patientin wird sofort auf der Intensivstation aufgenommen und erhält Analgetika, Flüssigkeitssubstitution und ein pankreasgängiges Antibiotikum zur Verhinderung einer Infektion der Pankreasnekrosen. Nach 2½ Tagen Nachweis bräunlich-grünlicher Hautverfärbungen im Nabelbereich (Cullen-Zeichen) und 1 Tag später auch in beiden Flanken (Grey-Turner-Zeichen). Am 5. Tag Abfall der arteriellen Sauerstoffspannung trotz nasaler Sauerstoffgabe, Beatmungsindikation. 2 Tage später muss wegen ansteigender Kreatininwerte mit einem Dialyseverfahren begonnen werden. Zum gleichen Zeitpunkt bei vorhandenen Darmgeräuschen Beginn einer enteralen Nahrungszufuhr über eine endoskopisch in den Dünndarm platzierte Sonde. Trotz aller therapeutischen Maßnahmen ab dem 14. Tag Entwicklung eines septischen Krankheitsbildes, dem die Patientin am 20. Krankheitstag erliegt. Die Sektion zeigt eine Totalnekrose des Pankreas.*Modifizierter Nachdruck (s. www.falkfoundation.de) mit freundlicher Genehmigung.

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Pankrin

Cited by 5 publications

References 7 publications

Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model

Metabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model

Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis

Akute Pankreatitis: Worauf es wirklich ankommt in der Diagnostik und der Therapie*

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