Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study

M, Verdier; Anuardo, Pedro; Gormezano, Natali W.S.; Romiti, Ricardo; Campos, Lúcia Maria Arruda; Aikawa, Nádia E.; Pereira, Rosa Maria Rodrigues; Terreri, Maria Teresa; Magalhães, Cláudia Saad; Ferreira, Juliana Carvalho; Silva, Marco Felipe Castro; Ferriani, Mariana Paes Leme; Sakamoto, Ana Paula; Ferriani, Virgínia Paes Leme; Centeville, Maraísa; Sato, Juliana de Oliveira; Santos, Maria Carolina dos; Bonfá, Eloísa; Silva, Clóvis A.

doi:10.1186/s42358-019-0049-9

Cited by 5 publications

(13 citation statements)

References 26 publications

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“…It manifests as subcutaneous painful nodules mainly affecting the upper extremities, face, scalp and trunk 53,54 . It is more common in females, and may occur in children 55 . The overlying skin may appear normal or display changes of DLE 56,57 .…”

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of lupus erythematosus: a practical clinicopathological review for pathologists

2021

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Accurate diagnosis of connective tissue diseases is often challenging, and relies upon careful correlation between clinical and histopathological features, direct immunofluorescence studies and laboratory work‐up. Lupus erythematosus (LE) is a prototype of connective tissue disease with a variety of cutaneous and systemic manifestations. Microscopically, cutaneous LE is classically characterised by an interface dermatitis although other histopathological patterns also exist, depending upon the clinical presentation, location and chronicity of the skin lesions. In this article, we review the clinical, serological, histopathological and direct immunofluorescence findings in LE‐specific and LE non‐specific skin lesions, with an emphasis upon lesser‐known variants, newly described features and helpful ancillary studies. This review will guide general pathologists and dermatopathologists in accurately diagnosing and subclassifying cutaneous LE.

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Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of lupus erythematosus: a practical clinicopathological review for pathologists

2021

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“…LP most often presents as recurrent subcutaneous nodules or plaques, sometimes ulcerated that may heal with scarring and lipoatrophy. [1][2][3][4][5] In children, the most commonly involved areas are the face and upper limbs (66% and 40% of cases, respectively), [3][4][5] while lower limbs are involved in few cases (20%). [3][4][5] LP can arise on its own or in association with systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE).…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] In children, the most commonly involved areas are the face and upper limbs (66% and 40% of cases, respectively), [3][4][5] while lower limbs are involved in few cases (20%). [3][4][5] LP can arise on its own or in association with systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE). In children with LP, the risk of progression to SLE is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…In children with LP, the risk of progression to SLE is unknown. [3][4][5] LP may also be present in association with other connective tissue disorders, such as scleroderma or polymyositis. [6][7][8] The differential diagnosis for LP includes erythema nodosum, pancreatic panniculitis, morphea profunda, cold panniculitis, panniculitis associated with interferonopathies, 9 and subcutaneous panniculitis-like T-cell lymphoma (SPTCL), which may be clinically identical to LP.…”

Section: Discussionmentioning

confidence: 99%

“…10 Laboratory testing, including ANA, ENA, inflammatory markers, complement, and CBC, can be normal as in our case, so histopathology is crucial to confirm a diagnosis of LP. [1][2][3][4] Histopathologic features of LP are characterized by a lobular panniculitis with limited extension into adjacent septa, predominant lymphoplasmacytic infiltrate, clusters of plasmacytoid dendritic cells, hyalinizing fat necrosis and paraseptal nodular lymphocytic aggregates with plasma cells. [1][2][3][4] Features of lupus erythematosus, such as follicular plugging and vacuolar alteration at the dermo-epidermal junction or superficial and deep perivascular lymphocytic infiltrate with histiocytes and plasma cells can be seen.…”

Section: Discussionmentioning

confidence: 99%

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