Panniculitis in Dermatomyositis

Антелава, Ольга Алексеевна; Егорова, О. Н.; Белов, Б. С.; Раденска-Лоповок, С Г; Khelkovskaia-Sergeeva, A.; Glukhova, S.

doi:10.14412/1995-4484-2016-227-232

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…По современным данным, 10 % всех известных случаев панникулита Крисчена-Вебера заканчиваются летальным исходом, часть из которых может быть связана с не до конца диагностированными панникулитоподобными лимфомами [12,25]. Обсуждение и заключение В литературе имеются немногочисленные сообщения о сочетании панникулита с другими заболеваниями: саркоидоз, дерматомиозит, ревматоидный артрит, миелобластный лейкоз [8,9,26].…”

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Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

Торгашова

Барабанова

Порханов

et al. 2019

Neuromuscular Diseases

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Christian–Weber disease refers to the group of panniculitis, which present an inflammation of the subcutaneous adipose tissue with the involvement of neutrophils, white blood cells and histiocytics, which leads to fibrosis in adipose tissue and sometimes to granulomatous changes. Clinically this pathology manifests from the formation of nodes in the subcutaneous adipose tissue, which appear suddenly, sporadically in some areas or multiple, sometimes forming large aggregations (plaques) or strands, shaped like a rosary. Consistency of nodes initially soft, then compacted, can form adhesions with the skin, the skin over them is not changed initially, followed by a color change from bright pink to brown-purple. Ends the process of atrophy of the affected area, sometimes with a depression in the center. Localization sites in the body are different; they are placed often on the buttocks, arms and legs. The duration of the process of the skin varies from a few days to a few months, after involution of old nodes may appear new ones, it are the cause of increasing the duration of the disease, having a relapsing course. It can be rather difficult to do differential diagnosis, which requires a great deal of experience of experts and a team approach to the study and treatment of this pathology. To confirm the diagnosis requires a biopsy of the skin. Prognosis depends on the nature of the disease and timely diagnosis.

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Section: Introductionunclassified

Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

Торгашова

Барабанова

Порханов

et al. 2019

Neuromuscular Diseases

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Morphological features of lobular panniculitis in systemic lupus erythematosus and dermatomyositis

Musatov

Раденска-Лоповок

Егорова³

et al. 2022

Sovremennaâ revmatologiâ

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The article presents a review of current data on the morphological features of lobular panniculitis (PN) associated with systemic lupus erythematosus (SLE) and dermatomyositis (DM). The clinical and morphological characteristics of PN are presented. The prospects for the use of histological and immunohistochemical methods for the differential diagnosis of PN in SLE and DM are discussed. As the analysis of published works has shown, there are no specific immunomorphological markers of PN. Further research is needed to improve the diagnosis of PN.

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Dystrophic calciphylaxis in panniculitis: features of the clinical picture and diagnosis

Egorova,

Datsina,

Severinova

2023

Sovremennaâ revmatologiâ

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The clinical presentation of lobular panniculitis (PN) associated with calciphylaxis (CP, calcification) can vary widely and may be associated with joint and internal organs involvement, making the diagnosis of the disease difficult.Objective: to evaluate the frequency and significance of CP in patients with PN using long-term prospective follow-up.Material and methods. From 2018 to 2023, at the V.A. Nasonova Research Institute of Rheumatology 217 patients with referral diagnosis "erythema nodosum" or "panniculitis" were examined. In 19.3% of cases (9 men and 33 women aged 37 to 72 years) CP was confirmed with an average disease duration of 56.3±11.2 months. Clinical examination of patients was performed according to the standards recommended by the Russian Association of Rheumatologists. International criteria were used to confirm the diagnosis of systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SS), and lipodermatosclerosis (LDS). In 12 patients with indurations, pathological examination of biopsy specimens of skin and subcutaneous fatty tissue from the area of induration was performed, which allowed confirming the diagnosis of idiopathic lobular PN (ILPN) in 3 cases. Four grades of calcification were distinguished according to the size and depth of the calcifications. In addition, considering the type of radiological changes and clinical manifestations, four subtypes of CP were identified: mousse-like, stone-like, mesh-like and lamellar-like.Results and discussion. In the study group, the ratio of women to men was 3.6:1, and the mean age was 43.8±7.6 years. On clinical examination we determined, in 60% of cases CP predominantly stone-like subtype (71.4%) of first grade (47.6%), which was significantly more frequently located on the upper and/or lower extremities and/or trunk (57.1%; p=0.05). Using clinical, laboratory and instrumental data, we confirmed the development of CP in ILPN (n=3), SLE (n=3), LDS (n=21), IIM (n=5), SS (n=1), and idiopathic CP (n=9) with a mean disease duration of 8.7±2.4 years.An increase in ESR and CRP levels occurred in different diseases, while urinary syndrome was associated with SLE (66.6%) and an increase in creatinine phosphokinase with IIM. Decreased calcium and 25-hydroxyvitamin D levels and increased phosphorus and parathyroid hormone levels were found in many patients studied.Conclusion. In the absence of clear diagnostic criteria for CP in patients with PN, early diagnosis is critical for the development of an effective multidisciplinary treatment plan.

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Panniculitis in Dermatomyositis

Cited by 4 publications

References 12 publications

Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

Christianic–Weber panniculitis in a young patient with myasthenia (description of clinical case)

Morphological features of lobular panniculitis in systemic lupus erythematosus and dermatomyositis

Dystrophic calciphylaxis in panniculitis: features of the clinical picture and diagnosis

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