2013
DOI: 10.1039/c3ra22596h
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Panorama of poly-ε-lysine

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Cited by 47 publications
(36 citation statements)
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References 134 publications
(259 reference statements)
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“…ε-PL has been known as an antibacterial polyamine secreted mainly by some bacteria in the Streptomycetaceae family [25] and a few members of the Bacillaceae family [26,27]. Production of ε-PL in fungi has also been reported for Clavicipitaceae fungi, including ergot fungi Claviceps purpurea [28] and Epichloë sp.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ε-PL has been known as an antibacterial polyamine secreted mainly by some bacteria in the Streptomycetaceae family [25] and a few members of the Bacillaceae family [26,27]. Production of ε-PL in fungi has also been reported for Clavicipitaceae fungi, including ergot fungi Claviceps purpurea [28] and Epichloë sp.…”
Section: Discussionmentioning
confidence: 99%
“…Among the constructed transformants, Ptef::Epls (E437) was the best producer of ε-PL (approximately 70 mg/L). Since ε-PL has attracted attention as an antimicrobial agent with a wide inhibitory spectrum against Gram-positive and negative bacteria, fungi, yeasts, and phages [25], several strategies to improve the production of ε-PL have been conducted; for example, modifying culture conditions (supplementation with glucose or other metabolic precursors, modifying pH, etc.) [27,34], inducing double antibiotic-resistant mutations [35] and genome shuffling [36].…”
Section: Discussionmentioning
confidence: 99%
“…Apart from its use in food industry, it finds numerous applications in pharmaceutical industry as a drug carrier, as nanoparticles, as gene carrier, as liposomes, as interferon inducer, as lipase inhibitor, as hydrogel, as coating material, etc. (Bankar and Singhal 2013 ). Considering its wide array of applications, ε-PL has become a molecule of great interest and is gaining a lot of importance.…”
Section: Introductionmentioning
confidence: 97%
“…Hence, ɛ-PL has been extensively investigated in food, agricultural, pharmaceutical, and cosmetic industries. More detailed descriptions of these applications with ɛ-PL are available elsewhere (Bankar and Singhal 2013;Chheda and Vernekar 2015b;Pandey and Kumar 2014;Shih et al 2006;Shukla et al 2012). Among such a vast application, ɛ-PL is mainly used as a natural food preservative because of its safety, heat stability, biodegradability, and broad-spectrum antimicrobial activity (Shih et al 2006;Shima et al 1984).…”
Section: Introductionmentioning
confidence: 99%