Panoramic view of common fusion genes in a large cohort of Chinese <i>de novo</i> acute myeloid leukemia patients

Chen, Xue; Wang, Fang; Zhang, Yang; Wang, Mangju; Tian, Wenjun; Teng, Wen; Ma, Xiaoli; Guo, Lei; Fang, Jiancheng; Zhang, Ying; Zhu, Ping; Liu, Hongxing

doi:10.1080/10428194.2018.1516876

Cited by 22 publications

(20 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, conventional cytogenetic analysis of bone marrow cells revealed a complex karyotype with t(9;22): 51, X, del(X)(p22.3), t(9;22)(q34;q11), +10, +?10, +19, +20, +der(22) t(9;22)(q34;q11). Molecular study confirmed BCR‐ABL1 translocation with p210 fusion transcript, and no p190 transcript was detected . Based on these findings, a diagnosis of CML accelerated phase with p210 BCR/ABL1 and monocytosis was rendered.…”

Section: Case Presentationmentioning

confidence: 89%

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

Wang¹,

Wang

et al. 2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Section: Case Presentationmentioning

confidence: 89%

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

Wang¹,

Wang

et al. 2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…In this study, 36 commonly reported FGs in hematological malignancies in a large cohort of Chinese acute leukemia patients were retrospectively analyzed. 6,7 It was found that 23 FGs were detected in 1292 (41.21%) of 3135 acute myeloid leukemia (AML) cases, and 17 FGs were detected in 712 (28.72%) of 2479 acute lymphoblastic leukemia (ALL) cases. The co-occurrence of two FGs was observed in only 0.22% of AML and 0.24% of ALL patients.…”

Section: Traditional Methods and Limitations Of Fgs Identificationmentioning

confidence: 99%

“…Today, screening multiple FGs simultaneously and then quantitatively monitoring the positive ones has become a routine clinical application. [6][7][8]…”

Section: Introductionmentioning

confidence: 99%

Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies

Chen

Wang

et al. 2019

Int J Med Rev

Self Cite

View full text Add to dashboard Cite

Fusion genes (FGs) are major molecular biological abnormalities in hematological malignancies and have become well-established molecular markers for disease classification, risk stratification, and targeted therapies. The long tail phenomenon is observed in the distribution of FGs, which means that except for dozens of the most common FGs, the positive rates of the other FGs are all below 1%, even if they have been frequently reported in the literature. However, the total positive rate of these singly relatively rare FGs is actually not low due to their wide variety and numerous members. We therefore put forward the conception "fusion gene family, FG-FM" to describe fusions that share one common protagonist gene with different partner genes. Most of the FGs in hematological malignancies discovered to date can be classified into about 20 major families. Based on the characteristics of the currently reported FGs, it can be expected that although a great many FGs may be identified in the future, the total number of FG-FMs is rather limited. FGs in the same FG-FM often have similarities in pathogenicity, clinical features, and treatment outcomes. Classifying FGs according to FG-FMs will aid in understanding their pathogenicity and optimizing detection schemes.

show abstract

“…We have previously reported common FGs were presented in ~41% of acute myeloid leukemia (AML) and 29% of acute lymphoblastic leukemia (ALL) cases, respectively [ 2 , 3 ]. The distribution of FGs in acute leukemia presented a typical long-tail phenomenon, which meant that several FGs with high-frequencies were followed by a large number of FGs with low-frequencies which gradually “tails off” asymptotically.…”

Section: Introductionmentioning

confidence: 99%

Fusion gene map of acute leukemia revealed by transcriptome sequencing of a consecutive cohort of 1000 cases in a single center

et al. 2021

Self Cite

View full text Add to dashboard Cite

Fusion genes (FGs) are important genetic abnormalities in acute leukemias, but their variety and occurrence in acute leukemias remain to be systematically described. Whole transcriptome sequencing (WTS) provides a powerful tool for analyzing FGs. Here we report the FG map revealed by WTS in a consecutive cohort of 1000 acute leukemia cases in a single center, including 539 acute myeloid leukemia (AML), 437 acute lymphoblastic leukemia (ALL), and 24 mixed-phenotype acute leukemia (MPAL) patients. Bioinformatic analysis identified 792 high-confidence in-frame fusion events (296 distinct fusions) which were classified into four tiers. Tier A (pathogenic), B (likely pathogenic), and C (uncertain significance) FGs were identified in 61.8% cases of the total cohort (59.7% in AML, 64.5% in ALL, and 63.6% in MPAL). FGs involving protein kinase, transcription factor, and epigenetic genes were detected in 10.7%, 48.5%, and 15.1% cases, respectively. A considerable amount of novel FGs (82 in AML, 88 in B-ALL, 13 in T-ALL, and 9 in MPAL) was identified. This comprehensively described real map of FGs in acute leukemia revealed multiple FGs with clinical relevance that have not been previously recognized. WTS is a valuable tool and should be widely used in the routine diagnostic workup of acute leukemia.

show abstract

Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients

Cited by 22 publications

References 27 publications

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies

Fusion gene map of acute leukemia revealed by transcriptome sequencing of a consecutive cohort of 1000 cases in a single center

Contact Info

Product

Resources

About

Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients

Cited by 22 publications

References 27 publications

p210BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

p210BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies

Fusion gene map of acute leukemia revealed by transcriptome sequencing of a consecutive cohort of 1000 cases in a single center

Contact Info

Product

Resources

About

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis