Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity

Abstract

Impaired wound healing is a common complication for diabetic patients and effective diabetic wound management remains a clinical challenge. Furthermore, a significant problem that contributes to patient morbidity is the suboptimal quality of healed skin, which often leads to reoccurring chronic skin wounds. Herein, a novel compound and biomaterial building block, panthenol citrate (PC), is developed. It has interesting fluorescence and absorbance properties, and it is shown that PC can be used in soluble form as a wash solution and as a hydrogel dressing to address impaired wound healing in diabetes. PC exhibits antioxidant, antibacterial, anti‐inflammatory, and pro‐angiogenic properties, and promotes keratinocyte and dermal fibroblast migration and proliferation. When applied in a splinted excisional wound diabetic rodent model, PC improves re‐epithelialization, granulation tissue formation, and neovascularization. It also reduces inflammation and oxidative stress in the wound environment. Most importantly, it improves the regenerated tissue quality with enhanced mechanical strength and electrical properties. Therefore, PC could potentially improve wound care management for diabetic patients and play a beneficial role in other tissue regeneration applications.

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

“…Citrate plays a crucial role as a bioactive factor in bone (62). Both mPOC and PPCN, integral components of the CSS, are polymers that belong to a biomaterial technology referred to as citrate-based biomaterials (CBB) (26,63). A CBB, referred to as CITREGEN, has been used for the fabrication of biodegradable implantable medical devices that have been cleared by the U.S. Food and Drug Administration (FDA) to attach soft tissue to bone (63).…”

“…Both mPOC and PPCN, integral components of the CSS, are polymers that belong to a biomaterial technology referred to as citrate-based biomaterials (CBB) (26,63). A CBB, referred to as CITREGEN, has been used for the fabrication of biodegradable implantable medical devices that have been cleared by the U.S. Food and Drug Administration (FDA) to attach soft tissue to bone (63). Therefore, given that the FDA is familiar with this new composition and class of polymers (biodegradable thermosets), the CSS is primed for translational application.…”

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

“…Human epidermal keratinocyte cell lines (HaCaT) were cultured in Dulbecco's modified Eagle's medium supplemented with 10 % fetal bovine serum, 1 % penicillin and streptomycin in a humidified incubator at 37 °C with 5 % CO 2 . After that, HA‐based hydrogels (HA hydrogel, CaCO 3 @HA hydrogel, and CPC@HA hydrogel) were immersed in 5 mL of culture medium for 24 h to obtain their corresponding extracts [56] …”

“…Then, 20 μL of the bacteria suspension was spread on an LB agar plate (15 mL of LB agar solution in a 10 mm petri dish). Subsequently, after 24 h incubation at 37 °C, the digital photos of each LB agar plate were taken [56] …”

Photopolymerized Multifunctional Hydrogel Loaded with Asiaticoside and Growth Factor for Accelerating Diabetic Wound Healing

“…The skin of diabetic patients very easily forms chronic wounds/ulcers that are difficult to heal after being damaged. , Long-term unhealed diabetic wounds not only increase the medical burden of patients but also may lead to amputation in patients in serious cases and even threaten their life safety. − At present, diabetic wounds are difficult to heal due to multiple bacterial infections, blocked blood circulation, and reduced collagen deposition, which has become one of the most difficult challenges in clinical treatment. − Therefore, it is desirable to develop an effective strategy to accelerate diabetic wound healing.…”