Pantoea dispersa: an unusual cause of neonatal sepsis

Mehar, Veerendra; Yadav, Dinesh Kumar; Sanghvi, Jyoti; Gupta, Nidhi; Singh, Kuldeep

doi:10.1016/j.bjid.2013.05.013

Cited by 46 publications

(31 citation statements)

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“…First case was reported in Germany in a 71-year-old woman with respiratory infection, 1 and recently, Mehar et al described two neonatal cases in India. 2 We herein report another clinical case of P. dispersa infection from Japan.A 64-year-old man with dilated cardiomyopathy, sick sinus syndrome and diabetes mellitus was admitted to our hospital for control of chronic heart failure. A central venous catheter (CVC) was inserted and a permanent pacemaker was embedded 10 days after admission.…”

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Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

Hagiya

Otsuka

2014

The Brazilian Journal of Infectious Diseases

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Genus Pantoea is a rare pathogen in clinical settings. Among seven species of the rare organism, Pantoea agglomerans is the most prominent species in humans and clinical cases of Pantoea dispersa infection have scarcely been described. First case was reported in Germany in a 71-year-old woman with respiratory infection, 1 and recently, Mehar et al. described two neonatal cases in India. 2 We herein report another clinical case of P. dispersa infection from Japan.A 64-year-old man with dilated cardiomyopathy, sick sinus syndrome and diabetes mellitus was admitted to our hospital for control of chronic heart failure. A central venous catheter (CVC) was inserted and a permanent pacemaker was embedded 10 days after admission. Approximately two months later, he suddenly had high fever with shivering. Blood cultures were obtained and the CVC was removed, suspecting central line-associated bloodstream infection. A Gram-negative rod was detected from both blood and catheter tip cultures, and the organism was identified as belonging to the genus Pantoea by the Vitek2 system (bioMérieux, France) and rapid ID 32 system (bioMérieux, France). Finally, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis identified the isolate as P. dispersa with a score value of 2.344. The pathogen was sensitive to ceftazidime, cefepime, imipenem, gentamycin, and levofloxacin, and administration of cefepime was initiated. A follow-up blood culture became positive again, and the pacemaker was removed with suspicion of pacemaker infection. The persistent bacteremia then disappeared. A total of four weeks of antibiotic therapy was completed without recurrence of infection.Epidemiology and clinical features of P. dispersa infection are still unknown due to its rarity and difficulty in accurate identification. For a more comprehensive understanding, bacterial identification should be accurately performed. However, due to the similarity in bacterial properties of species of the genus Pantoea, biochemical identification alone would not be appropriate and may even be misleading. For example, more than 10% of clinical isolates of P. agglomerans were misidentified as species of the genus Enterobacter by the VITEK MS system (bioMérieux, Marcy l'Etoile, France). 3 In those two previous cases of P. dispersa infection, 1,2 API 50 CHE system and Vitek2 system were used, and thus, accuracy of the identification was not known. Usually, 16S rRNA gene sequencing is used for the reference of bacterial identification; however, nucleotide sequences of P. dispersa have not been deposited in gene databases. Even if the sequence are known, results of analysis may not be correct; according to a recent report, only half of the clinical isolates of P. agglomerans (9/18 cases) were identified correctly by 16S rRNA analysis. 4 We identified the pathogen by means of MALDI-TOF MS analysis. Although the clinical utility of MALDI-TOF MS analysis for accurate identification of genus Pantoea is still unestablished, Richter et al. ...

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Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

Hagiya

Otsuka

2014

The Brazilian Journal of Infectious Diseases

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“…[ 12 13 ] This was followed by apparently the self-proclaimed, first report of neonatal sepsis involving this subspecies in central India. [ 14 ] In 2014, there was a reported case of P dispersa , being the cause of bacteremia via a central line, again an opportunistic invasion. [ 15 ] Surprisingly, in another report from Iraq, the majority of samples contained P. agglomerans , followed by Pantoea ananatis and Pantoea calida .…”

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Pantoea dispersa it the next emerging “monster” in our intensive care units? A case report and review of literature

Panditrao

2018

Anesth Essays Res

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“…[36][37][38][39][40][41][42][43][44] Los primeros casos reportados se asociaron a brotes por contaminación de infusiones para nutrición parenteral. 38 Aunque se han descrito infecciones por otros tipos de Pantoea, 45 la infección por P. agglomerans es la más frecuente. En el Cuadro 1 se resumen los casos reportados de sepsis neonatal por esta bacteria con las principales características y se comparan con el caso presentado.…”

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Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

2018

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Este artículo debe citarse comoGálvez-Cuitiva EA, Peralta-Palmezano JJ, LonngiRojas G. Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura. Acta Pediatr Mex. 2018;39(1):52-59. Resumen INTRODUCCIÓN:Pantoea Agglomerans es un bacilo gramnegativo miembro de la familia Enterobacteriaceae, de distribución ubicua que, bajo ciertas circunstancias, puede tener un comportamiento patóge-no en el ser humano. Son pocos los casos de infección neonatal no asociados al cuidado de la salud descritos en la literatura; ninguno de ellos reportado en Colombia. PRESENTACIÓN DEL CASO: niña recién nacida, pretérmino, que desde su primer día presentó una inadecuada adaptación neonatal, con dificultad respiratoria, sepsis y un rápido deterioro clínico, lo cual requirió manejo y soporte en la unidad de cuidados intensivos neonatales. Se aisló por hemocultivos P. agglomerans, susceptible al manejo antibiótico instaurado, con una respuesta adecuada, así como una evolución clínica favorable. CONCLUSIÓN: la sepsis neonatal por P. agglomerans es poco frecuente, por lo que su desenlace dependerá de muchos factores: la detección temprana, la asistencia oportuna y el manejo adecuado que se brinde. PALABRAS CLAVE:Pantoea agglomerans, sepsis temprana, recién nacido, pretérmino. Early Sepsis in a Preterm Newborn by

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Pantoea dispersa: an unusual cause of neonatal sepsis

Cited by 46 publications

References 10 publications

Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

Pantoea dispersa it the next emerging “monster” in our intensive care units? A case report and review of literature

Sepsis temprana en un recién nacido pretérmino por Pantoea agglomerans: informe de caso y revisión de la literatura

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