Pantoea species sepsis associated with sickle cell crisis in a pregnant woman with a history of pica

Achkar, Morhaf Al; Rogers, Jordan S.; Muszynski, Michael J.

doi:10.12659/ajcr.882588

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…In the previously reported cases of patients with SCD infected with Pantoea [14][15][16], the possibility of gut translocation of the bacteria was raised, as one of the three reported cases was of a pregnant lady with SCD having a history of long-standing geophagia (i.e., potting soil consumption). The second case was of a child with a history of soil ingestion who was found to have Pantoea bacteremia.…”

Section: Discussionmentioning

confidence: 99%

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Pantoea Species Bacteremia in a Child With Sickle Cell Disease: A Case Report

Aljameely,

AlZubaidi,

AlSiny

et al. 2024

Cureus

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The Pantoea genus of bacteria is a group of Gram-negative rod-shaped bacteria in the Enterobacteriaceae family. It is an uncommon cause of infection in humans except in specific settings, including hospitalacquired infections and in immunocompromised patients.In this report, we describe the case of a 12-year-old girl with sickle cell disease who presented with a picture of sepsis and was found to have Pantoea species in her blood culture which was treated with antibiotics with a good response.From our literature review, risk factors were identified in the reported cases, for which further exploration is highly recommended.

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Section: Discussionmentioning

confidence: 99%

“…Through a review of the literature, we found that the incidence of Pantoea infection in patients with SCD has only been reported three times [15][16][17]. Therefore, this is the fourth report of a patient with SCD who was found positive for Pantoea spp.…”

Section: Introductionmentioning

confidence: 86%

Pantoea Species Bacteremia in a Child With Sickle Cell Disease: A Case Report

Aljameely,

AlZubaidi,

AlSiny

et al. 2024

Cureus

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“…Klebsiella pneumonia and Staphylococcus aureus are two other bacteria that can cause bacteremia and septicemia [66]. Salmonella species and Pantoea agglomerans enteric Gram-negative bacteria also negatively impact SCD patients [67,68]. An extensive data analysis of 550 SCD patients shows that the use of catheters during red cell exchange/transfusion increased the risk of bacteremia or thrombosis [69].…”

Section: Infectious Complications Associated With Scdmentioning

confidence: 99%

Infection and Potential Challenge of Childhood Mortality in Sickle Cell Disease: A Comprehensive Review of the Literature from a Global Perspective

Sahu,

Pande,

Verma

et al. 2023

Thalassemia Reports

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Sickle cell disease (SCD) is a complex genetic disorder associated with multiple clinical manifestations, including increased susceptibility to bacterial and viral infections. This review article presents a comprehensive analysis of the current literature obtained from various online databases focusing on the relationship between SCD and infections caused by specific pathogens, such as pneumonia- and influenza-causing pathogens, Escherichia coli, Staphylococcus aureus, parvovirus, and hepatitis viruses. We discuss the underlying mechanisms that contribute to the increased susceptibility of individuals with SCD to these infections, primarily related to the pathophysiology of variant hemoglobin (HbSS) and its impact on vascular occlusion, hemolysis, functional asplenia, and immune deficiency. Moreover, we highlight the significant burden of infections on SCD patients, particularly children under five years of age, where they are the leading cause of morbidity and mortality. Additionally, we address the challenges faced in attempts for reducing the global mortality rate associated with SCD, particularly in low-income countries, where factors such as increased pathogen exposure, co-morbidities like malnutrition, lower vaccination rates, and limited healthcare facilities contribute to the high disease burden. This review emphasizes the need for targeted interventions, improved healthcare access, vaccination programs, and infection prevention strategies to alleviate the impact of infections on individuals with SCD and reduce the global mortality rates associated with the disease.

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“…In recent years, sepsis incidence has been rising due to the growing elderly population, prolonged hospitalization, and increasingly aggressive medical procedures; thus, sepsis is causing a significant epidemiological and public health concern [ 3 ]. Nosocomial infectious diseases resulting from contaminated blood products, intravenous fluid, and medications have been reported [ 4 ]. The sepsis mortality rates vary from 12.8% (sepsis) and 20.7% (severe sepsis) to 45.7% (septic shock) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Aloe-Emodin-Mediated Photodynamic Therapy Attenuates Sepsis-Associated Toxins in Selected Gram-Positive Bacteria In Vitro

Odhiambo

Liu

2021

J. Microbiol. Biotechnol.

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Sepsis is an acute inflammatory response that leadsto life-threatening complications if not quickly and adequately treated. Cytolysin, hemolysin, and pneumolysin are toxins produced by grampositive bacteria and are responsible for resistance to antimicrobial drugs, cause virulence and lead to sepsis. This work assessed the effects of aloe-emodin (AE) and photodynamic therapy (PDT) on sepsis-associated gram-positive bacterial toxins. Standard and antibiotic-resistant Enterococcus faecalis, Staphylococcus aureus, and Streptococcus pneumonia bacterial strains were cultured in the dark with varying AE concentrations and later irradiated with 72 J/cm -2 light. Colony and biofilm formation was determined. CCK-8, Griess reagent reaction, and ELISA assays were done on bacteriainfected RAW264.7 cells to determine the cell viability, NO, and IL-1β and IL-6 pro-inflammatory cytokines responses, respectively. Hemolysis and western blot assays were done to determine the effect of treatment on hemolysis activity and sepsis-associated toxins expressions. AE-mediated PDT reduced bacterial survival in a dose-dependent manner with 32 μg/ml of AE almost eliminating their survival. Cell proliferation, NO, IL-1β, and IL-6 cytokines production were also significantly downregulated. Further, the hemolytic activities and expressions of cytolysin, hemolysin, and pneumolysin were significantly reduced following AE-mediated PDT. In conclusion, combined use of AE and light (435 ± 10 nm) inactivates MRSA, S. aureus (ATCC 29213), S. pneumoniae (ATCC 49619), MDR-S. pneumoniae, E. faecalis (ATCC 29212), and VRE (ATCC 51299) in an AE-dose dependent manner. AE and light are also effective in reducing biofilm formations, suppressing proinflammatory cytokines, hemolytic activities, and inhibiting the expressions of toxins that cause sepsis.

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Pantoea species sepsis associated with sickle cell crisis in a pregnant woman with a history of pica

Cited by 7 publications

References 12 publications

Pantoea Species Bacteremia in a Child With Sickle Cell Disease: A Case Report

Pantoea Species Bacteremia in a Child With Sickle Cell Disease: A Case Report

Infection and Potential Challenge of Childhood Mortality in Sickle Cell Disease: A Comprehensive Review of the Literature from a Global Perspective

Aloe-Emodin-Mediated Photodynamic Therapy Attenuates Sepsis-Associated Toxins in Selected Gram-Positive Bacteria In Vitro

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