Pantoprazol-induzierte Hepatitis

Abstract

Intake of proton pump inhibitors is a rare cause but should be considered in the differential diagnosis of hepatitis of uncertain etiology.

Immune‐mediated drug‐induced liver injury secondary to Omeprazole: A case report

“…Some of the drugs known to cause autoimmune type DILI are clometacin, diclofenac, fenofibrate, methyldopa, minocycline, nitrofurantoin, papaverine, phenytoin, propylthiouracil, and statins, among others 12 . PPI are also associated with DILI, with a few reported cases 18‐32 . Although omeprazole is the most common PPI associated with DILI, to the best of our knowledge, it has not been reported with the AIH DILI pattern.…”

“…12 PPI are also associated with DILI, with a few reported cases. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Although omeprazole is the most common PPI associated with DILI, to the best of our knowledge, it has not been reported with the AIH DILI pattern. Previously reported patterns of DILI with omeprazole are pure hepatocellular, cholestatic, and mixed hepatitis with negative antibodies.…”

Response to “Acute Hepatitis Induced by Lyprinol, the Lipid Extract of the Green-Lipped Mussel (Perna canaliculus), in a Patient with Polyarthrosis”

“…The strength of the association in a single case report is determined by the absence of potential confounding factors. An important potential confounder in this case is that pantoprazole, which was being taken concomitantly with Lyprinol, has itself been the subject of multiple case reports of acute liver toxicity [ 5 – 7 ]. This confounder appears to be ruled out by the authors as the medication was stable at the time of the acute hepatitis.…”