2017
DOI: 10.5664/jcsm.6858
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PAP and Cardiovascular Events in Adults With Sleep Apnea: Is PAP Useful?

Abstract: In individuals with obstructive sleep apnea (OSA) or central sleep apnea (CSA), does the treatment of sleep apnea with positive airway pressure therapy (PAP) reduce the incidence of the primary composite end point (acute coronary syndrome [ACS] events, stroke, or vascular death [major adverse cardiovascular events]; cause-specific vascular events; and death)? Methods DesignA meta-analysis of randomized controlled trials (RCTs) of sleep apnea and the effect of PAP therapy on cardiovascular events. Data Sources … Show more

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Cited by 8 publications
(7 citation statements)
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“…Meta‐analyses with overall low to moderate homogeneity of included studies are shown in Table 2. The recent MA by Yu et al., comprising patients with both OSA and CSA, was largely driven by the results of the Sleep Apnea Cardiovascular Endpoints (SAVE) trial and did not show a reduction in major adverse CV events 654,1212 . However, a borderline statistically significant ( p = 0.05) reduction of systolic BP with PAP was noted.…”
Section: Medical Treatment For Osamentioning
confidence: 99%
“…Meta‐analyses with overall low to moderate homogeneity of included studies are shown in Table 2. The recent MA by Yu et al., comprising patients with both OSA and CSA, was largely driven by the results of the Sleep Apnea Cardiovascular Endpoints (SAVE) trial and did not show a reduction in major adverse CV events 654,1212 . However, a borderline statistically significant ( p = 0.05) reduction of systolic BP with PAP was noted.…”
Section: Medical Treatment For Osamentioning
confidence: 99%
“…Mainly, oxygen desaturation seems to be responsible for cardiovascular health related issues [ 164 ] and may contribute to neurodegeneration in PD. However, controversies regarding the impact of SBD on cardiovascular events and the extent of preventive effects of treating SDB in the general population are ongoing [ 165 ].…”
Section: Specific Sleep Disorders: Diagnostics and Treatmentmentioning
confidence: 99%
“…The efficacy of PAP treatment has been demonstrated in the elderly, in PD and even in Alzheimer’s disease patients [ 172 ]. However, the contribution of PAP treatment of SDB to the prevention of cardiovascular diseases in the general population has been controversially disputed lately [ 165 ]. Nonetheless, considering the positive effects of improved sleep quality on patients and caregivers, effective treatment of SDB should be aspired.…”
Section: Specific Sleep Disorders: Diagnostics and Treatmentmentioning
confidence: 99%
“…The recent SAVE trial did not show a beneficial effect of CPAP on the composite end-point of major adverse cardiovascular events in subjects with existing cardiovascular disease but it should be noted that mean nightly usage of CPAP was 3.3 hours in this study which would be considered clinically inadequate 140,144 . In a meta-analysis of trials evaluating the effects of CPAP on cardiovascular outcomes, the results of which were largely driven by the SAVE trial, a borderline statistically significant response (p=0.05) was noted with regard to reduction in BP 145,146 .…”
Section: Effects Of Treatment Of Sleep Apnea On Hypertensionmentioning
confidence: 99%