Papaverine injection into the hindlimb circulation stimulates ventilation in sheep

Haouzi, Philippe; Hirsh, Judith; Gille, J.P.; Marchal, François; Crance, J. P.; Huszczuk, A

doi:10.1016/0034-5687(96)00012-6

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…Most of the group IV fibres responding to intermittent dynamic triceps surae contractions also responded to venous distension or to vasodilatory agents (Haouzi et al 1999). Using a similar approach in sheep, Haouzi et al (1996) demonstrated that limb peripheral venous distension increased ventilation and arterial pressure. The present result supports the observations in animals.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic responses during saline infusion into the veins of an occluded limb

Cui

McQuillan

Moradkhan

et al. 2009

The Journal of Physiology

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Animal studies have shown that the increased intravenous pressure stimulates the group III and IV muscle afferent fibres, and in turn induce cardiovascular responses. However, this pathway of autonomic regulation has not been examined in humans. The aim of this study was to examine the hypothesis that infusion of saline into the venous circulation of an arterially occluded vascular bed evokes sympathetic activation in healthy individuals. Blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) responses were assessed in 19 young healthy subjects during local infusion of 40 ml saline into a forearm vein in the circulatory arrested condition. From baseline (11.8 ± 1.2 bursts min −1 ), MSNA increased significantly during the saline infusion (22.5 ± 2.6 bursts min −1 , P < 0.001). Blood pressure also increased significantly during the saline infusion. Three control trials were performed during separate visits. The results from the control trial show that the observed MSNA and blood pressure responses were not due to muscle ischaemia. The present data show that saline infusion into the venous circulation of an arterially occluded vascular bed induces sympathetic activation and an increase in blood pressure. We speculate that the infusion under such conditions stimulates the afferent endings near the vessels, and evokes the sympathetic activation.

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Section: Discussionmentioning

confidence: 99%

Sympathetic responses during saline infusion into the veins of an occluded limb

Cui

McQuillan

Moradkhan

et al. 2009

The Journal of Physiology

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“…This review presents and discusses indirect and direct experimental evidence suggesting an alternative site of coupling between respiratory control and circulation. On the basis of animal and human studies, in which the peripheral circulation was altered at rest and during or after muscular exercise (29,31,37), it was considered that the change in volume of the postcapillary and/or venous network in the skeletal muscles produced by a vasodilation or by a venous blockade could affect V E. These observations led us to look more carefully into the possibility that a source of ventilatory stimulation may reside in the skeletal muscles, transmitted by group III and IV muscle afferent fibers (for review, see Refs. 48, 63, 65) but acting through a circulatory-linked stimulus of a mechanical nature (27).…”

mentioning

confidence: 99%

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Haouzi¹,

Chenuel²,

Huszczuk³

2004

Journal of Applied Physiology

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This review examines the evidence that skeletal muscles can sense the status of the peripheral vascular network through group III and IV muscle afferent fibers. The anatomic and neurophysiological basis for such a mechanism is the following: 1) a significant portion of group III and IV afferent fibers have been found in the vicinity and the adventitia of the arterioles and the venules; 2) both of these groups of afferent fibers can respond to mechanical stimuli; 3) a population of group III and IV fibers stimulated during muscle contraction has been found to be inhibited to various degrees by arterial occlusion; and 4) more recently, direct evidence has been obtained showing that a part of the group IV muscle afferent fibers is stimulated by venous occlusion and by injection of vasodilatory agents. The physiological relevance of sensing local distension of the vascular network at venular level in the muscles is clearly different from that of the large veins, since the former can directly monitor the degree of tissue perfusion. The possible involvement of this sensing mechanism in respiratory control is discussed mainly in the light of the ventilatory effects of peripheral vascular occlusions during and after muscular exercise. It is proposed that this regulatory system anticipates the chemical changes that would occur in the arterial blood during increased metabolic load and attempts to minimize them by adjusting the level of ventilation to the level of muscle perfusion, thus matching the magnitudes of the peripheral and pulmonary gas exchange.

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“…Recently, group III and IV afferents have been proposed to possess the ability to signal the degree of muscular hyperemia (10). Specifically, the hypothesis is that the increased volume of the venular and venous compartment stimulates mechanosensitive free nerve endings located close to the vascular network (6)(7)(8). This circulatory-related signal originating in the muscular circulation offers an additional control mechanism that could link the ventilatory and the cardiovascular control systems to metabolic demand during a dynamic exercise (4,31).…”

mentioning

confidence: 99%

“…Finally, several observations point to the existence of a neural link between the degree of distension of the peripheral vascular bed in the skeletal muscles and ventilatory (6)(7)(8)10) or circulatory (15) control in exercise. For instance, impeding the venous return from the postexercising muscle in dogs (10) provokes ventilatory changes that follow the expected change in hindlimb peripheral vascular distension or volume, regardless of the time course of the arterial blood pressure (BP).…”

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confidence: 99%

Responses of group III and IV muscle afferents to distension of the peripheral vascular bed

Haouzi

Hill

Lewis

et al. 1999

Journal of Applied Physiology

110

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This study was undertaken to test the hypothesis that group III and IV afferents with endings in skeletal muscle signal the distension of the peripheral vascular network. The responses of these slowly conducting afferents to pharmacologically induced vasodilation and to acute obstruction of the venous drainage of the hindlimbs were studied in barbiturate-anesthetized cats. Afferent impulses arising from endings in the triceps surae muscles were recorded from the L(7) and S(1) dorsal roots. Fifteen of the 48 group IV and 3 of the 19 group III afferents tested were stimulated by intra-aortic injections of papaverine (2-2.5 mg/kg). Sixty-two percent of the afferents that responded to papaverine also responded to isoproterenol (50 microg/kg). Seven of the 36 group IV and 2 of the 12 group III afferents tested were excited by acute distension of the hindlimb venous system. Four of the seven group IV afferents responding to venous distension also responded to papaverine (57 vs. 13% for the nonresponding). Finally, we observed that most of the group IV afferents that were excited by dynamic contractions of the triceps surae muscles also responded either to venous distension or to vasodilatory agents. These results are consistent with the histological findings that a large number of group IV endings have their receptive fields close to the venules and suggest that they can be stimulated by the deformation of these vascular structures when peripheral conductance increases. Moreover, such a mechanism offers the possibility of encoding both the effects of muscle contraction through intramuscular pressure changes and the distension of the venular system, thereby monitoring the activity of the veno-muscular pump.

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Papaverine injection into the hindlimb circulation stimulates ventilation in sheep

Cited by 9 publications

References 16 publications

Sympathetic responses during saline infusion into the veins of an occluded limb

Sympathetic responses during saline infusion into the veins of an occluded limb

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Responses of group III and IV muscle afferents to distension of the peripheral vascular bed

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