2009
DOI: 10.1590/s0101-60832009000500004
|View full text |Cite
|
Sign up to set email alerts
|

Papel da proteína Tau na fisiopatologia da demência frontotemporal

Abstract: Contexto: Sob a denominação demência frontotemporal (DFT) enquadram-se importantes síndromes demenciais de natureza degenerativa progressiva que acometem os lobos frontais e temporais em ambos os hemisférios. As DFTs podem ser agrupadas, segundo seus aspectos clínicos dominantes, em variante frontal, afasia progressiva não fluente e demência semântica. A proteína Tau tem papel importante na patogenia desses transtornos, e anormalidades conformacionais estão presentes em até 50% dos casos de DFT esporádica. Do … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0
3

Year Published

2020
2020
2023
2023

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 10 publications
(11 citation statements)
references
References 23 publications
0
8
0
3
Order By: Relevance
“…The diagnosis of DFT is usually proposed to classify approximately 15% to 20% of dementia syndromes. According to pathological criteria, it is estimated that 3% to 10% of cases diagnosed post-mortem correspond to DFTs, and this number is higher (20%) in cases of presenile degenerative dementia (de Paula et al, 2009).…”
Section: Frontotemporal Dementia (Ftd)mentioning
confidence: 99%
“…The diagnosis of DFT is usually proposed to classify approximately 15% to 20% of dementia syndromes. According to pathological criteria, it is estimated that 3% to 10% of cases diagnosed post-mortem correspond to DFTs, and this number is higher (20%) in cases of presenile degenerative dementia (de Paula et al, 2009).…”
Section: Frontotemporal Dementia (Ftd)mentioning
confidence: 99%
“…Tau protein accumulation in nerve or glial cells is seen as an important biological marker of tauopathies. Neurodegenerative mechanisms are directly related to changes in the isoforms of this protein (de Paula et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…In molecular imaging examinations, such as positron emission tomography (PET), which allows visualisation of the glucose metabolism in the brain, Ab plaques are observed in topographic areas involving the temporoparietal cortex. Nuclear magnetic resonance (NMR) has also shown atrophy of the medial, basal and lateral areas of the temporal lobe cortex and basal medial parietal regions (Hu et al, 2010;de Souza et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…[15,17] . Em pessoas diagnosticadas com a AD, os emaranhados neurofibrilares insolúveis e intracelulares da proteína Tau são encontrados no estágio hiperfosforilado comprometendo as funções biológicas e morfológicas dos neurônios [16,[18][19][20] .…”
Section: I1 Bases Moleculares Da Doença De Alzheimerunclassified