Paper-Based Biosensors for the Point-of-Care detection of human serum albumins – A Mini Review

Abstract

In this review, we will delve into the exciting world of paper-based biosensors for detecting biomarkers in blood, with a particular focus on detecting albumins. With the increasing need for simple, affordable, and accessible diagnostic tools, paper-based biosensors have emerged as a promising solution. These biosensors are low-cost, easy to fabricate, and offer high sensitivity and selectivity. They can detect a wide range of biomolecules, including proteins, enzymes, nucleic acids, and antibodies, making them ideal for applications such as disease diagnosis, drug discovery, and environmental monitoring. By utilizing the unique properties of paper, such as its porosity, wettability, and capillary action, researchers have been able to create various types of biosensors, including lateral flow assays, microfluidic paper-based analytical devices (μPADs), and electrochemical paper-based sensors. These biosensors have been successfully used to detect biomarkers in blood for various diseases, such as cancer, infectious diseases, and cardiovascular diseases. We will explore the latest developments in paper-based biosensors, including the use of novel materials and fabrication techniques, as well as their potential for point-of-care testing in resource-limited settings.