Paper‐Based, Chemiresistive Sensor for Hydrogen Peroxide Detection

Giaretta, Jacopo Emilio; Oveissi, Farshad; Dehghani, Fariba; Naficy, Sina

doi:10.1002/admt.202001148

Cited by 22 publications

(26 citation statements)

References 46 publications

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“…Therefore, detection of H 2 O 2 plays an essential role in health monitoring and quality control in various fields. 69 Bare and doped NiO thin-film electrodes were also utilized as nonenzymatic H 2 O 2 sensors. The amperometric responses of the electrodes were measured in 0.1 M NaOH electrolyte by the successive addition of H 2 O 2 .…”

Section: Resultsmentioning

confidence: 99%

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Nanometer-Thick Mn:NiO and Co:NiO Films for High Performance Nonenzymatic Biosensors

Tutel

Koylan

Tunca

et al. 2021

ACS Appl. Nano Mater.

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People with diabetes require regular blood sugar level monitoring, using commercial enzyme-based biosensors. There is a considerable need to develop biosensors with nonenzymatic electrodes to eliminate the drawbacks of enzymes. Nanostructured nickel oxide (NiO) thin films are highly promising materials for the development of nonenzymatic glucose and hydrogen peroxide (H 2 O 2 ) biosensors. Although the biosensor performance can be easily attained with nonenzymatic electrodes, their commercialization still requires development of cost-effective and mass-production methods. In this work, we demonstrate the use of ultrasonic spray deposited, nanometer-thick, manganese and cobalt doped NiO (Mn:NiO and Co:NiO) films on indium tin oxide (ITO) coated glass substrates for glucose sensing. Sensor characterization followed detailed materials characterization. Nanometer-thick Co:NiO film electrodes showed better glucose sensor performance than those of bare NiO and Mn:NiO electrodes. High sensitivity of 1.67 μA/μM•cm 2 , a low detection limit of 231 nM, and a fast response time of 5.4 s within the linear range of 16−308 μM were obtained from nanometer-thick Co:NiO film electrodes. Amperometric measurements showed significant electrode reproducibility and stability. Nanometer-thick Co:NiO film electrode was also used to demonstrate actual clinical glucose measurements using human blood serum as a glucose source. Moreover, all fabricated nanometer-thick film electrodes were also utilized as H 2 O 2 sensors. This work provides a novel approach for monitoring the biosensor performance using nanometer-thick doped NiO film electrodes. Obtained results demonstrated the potential of ultrasonic spray deposition method for the massproduction of high-performance nonenzymatic nanometer-thick film biosensors.

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Section: Resultsmentioning

confidence: 99%

“…In addition, H 2 O 2 is widely present in the food, textile, and pharmaceutical industries. Therefore, detection of H 2 O 2 plays an essential role in health monitoring and quality control in various fields . Bare and doped NiO thin-film electrodes were also utilized as nonenzymatic H 2 O 2 sensors.…”

Section: Resultsmentioning

confidence: 99%

Nanometer-Thick Mn:NiO and Co:NiO Films for High Performance Nonenzymatic Biosensors

Tutel

Koylan

Tunca

et al. 2021

ACS Appl. Nano Mater.

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“…Chemiresistive sensors offer a simpler sensing platform to detect the analyte and its concentration through resistance change in the sensing layer . In the past, several H 2 O 2 vapor and liquid chemiresistive sensors have been developed using organic molecules, , metal or metal oxide nanoparticles, − conducting polymers, , and carbon nanomaterials like graphene and carbon nanotubes (CNTs). , A polypyrrole-doped multiwalled CNT (MWCNT) sensor was developed that was capable of H 2 O 2 detection within a range of 0–20 mM in standard buffer solutions . Other conducting polymers such as polyaniline nanowires modified with silver nanoparticles and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) along with horseradish peroxidase have been used for H 2 O 2 detection.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 A polypyrrole-doped multiwalled CNT (MWCNT) sensor was developed that was capable of H 2 O 2 detection within a range of 0−20 mM in standard buffer solutions. 15 Other conducting polymers such as polyaniline nanowires modified with silver nanoparticles 14 and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) along with horseradish peroxidase 16 have been used for H 2 O 2 detection. The reported measuring range of polyaniline nanowires with silver nanoparticles was 2 −40 mM.…”

Section: Introductionmentioning

confidence: 99%

Reagent-Free Hydrogen Peroxide Sensing Using Carbon Nanotube Chemiresistors with Electropolymerized Crystal Violet

Patel

Saha

Kruse

et al. 2022

ACS Appl. Nano Mater.

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Hydrogen peroxide (H2O2) is an intermediate molecule generated in numerous peroxidase assays used to measure concentrations of biomolecules such as glucose, galactose, and lactate. Here, we develop a solid-state reagent-free chemiresistive H2O2 sensor, which can measure H2O2 over a wide measuring range of 0.5–1000 ppm (0.015–29.4 mM). The sensor was fabricated using a network of functionalized single-walled carbon nanotubes (SWCNTs) as a sensitive layer and a xurographically patterned gold leaf as a contact electrode. The SWCNTs were functionalized with crystal violet to impart selective detection of H2O2. The crystal violet was self-assembled on the SWCNT film and subsequently polymerized via cyclic voltammetry to improve its retention on the sensing layer. The functionalized sensor exhibited good selectivity against common interferents such as uric acid, urea, glucose, and galactose. In addition, the sensor was used to measure in situ H2O2 generated during peroxidase assays performed using enzymes like glucose oxidase. The sensor was tested in standard buffer solutions for both enzymes. The glucose oxidase assay was also demonstrated in spiked pooled human plasma samples. The glucose oxidase-coated sensor exhibited a glucose detection range of 2–20 mM in standard buffer and blood plasma solutions, with a good recovery rate (∼95–107%) for glucose measurements in blood plasma.

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“…Paper sensors have been widely used in point-of-care detection due to their simplicity, low cost, visual detection, portability and minimal sample consumption [18][19][20]. It can be useful for qualitative and quantitative analyses with a range of analysis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Mesoporous CuO Hollow Sphere Nanozyme for Paper-Based Hydrogen Peroxide Sensor

et al. 2021

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Point-of-care monitoring of hydrogen peroxide is important due to its wide usage in biomedicine, the household and industry. Herein, a paper sensor is developed for sensitive, visual and selective detection of H2O2 using a mesoporous metal oxide hollow sphere as a nanozyme. The mesoporous CuO hollow sphere is synthesized by direct decomposition of copper–polyphenol colloidal spheres. The obtained mesoporous CuO hollow sphere shows a large specific surface area (58.77 m2/g), pore volume (0.56 cm3/g), accessible mesopores (5.8 nm), a hollow structure and a uniform diameter (~100 nm). Furthermore, they are proven to show excellent peroxidase-like activities with Km and Vmax values of 120 mM and 1.396 × 10−5 M·s−1, respectively. Such mesoporous CuO hollow spheres are then loaded on the low-cost and disposable filter paper test strip. The obtained paper sensor can be effectively used for detection of H2O2 in the range of 2.4–150 μM. This work provides a new kind of paper sensor fabricated from a mesoporous metal oxide hollow sphere nanozyme. These sensors could be potentially used in bioanalysis, food security and environmental protection.

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Paper‐Based, Chemiresistive Sensor for Hydrogen Peroxide Detection

Cited by 22 publications

References 46 publications

Nanometer-Thick Mn:NiO and Co:NiO Films for High Performance Nonenzymatic Biosensors

Nanometer-Thick Mn:NiO and Co:NiO Films for High Performance Nonenzymatic Biosensors

Reagent-Free Hydrogen Peroxide Sensing Using Carbon Nanotube Chemiresistors with Electropolymerized Crystal Violet

Synthesis of Mesoporous CuO Hollow Sphere Nanozyme for Paper-Based Hydrogen Peroxide Sensor

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