Paper-based microfluidics in sweat detection: from design to application

Ye, Zhichao; Yuan, Yuyang; Zhan, Shaowei; Liu, Wei; Lü, Fang; Li, Tianyu

doi:10.1039/d2an01818g

Cited by 5 publications

(3 citation statements)

References 149 publications

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“…67 As an inexpensive and lightweight substrate, paper is an ideal option for microfluidic devices that are portable for immediate use. 68 These devices are made by patterning paper with hydrophobic structures to define hydrophilic channels that transport fluid through capillary action. 69 While most devices use colorimetric assays, 70 electrochemical, 71 chemiluminescence, 72 and electrochemiluminescence 71 methods can also be employed in paper-based devices.…”

Section: Microfluidics In Wearable Devicesmentioning

confidence: 99%

Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Apoorva,

Nguyen,

Sreejith

2024

Lab Chip

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Section: Microfluidics In Wearable Devicesmentioning

confidence: 99%

Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Apoorva,

Nguyen,

Sreejith

2024

Lab Chip

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“…Furthermore, several analytical paper-based devices for the quantification of biomarkers in sweat have been proposed in the literature [32][33][34], thus allowing a simple implementation on a wearable platform of the reported operating principle, detection approach, and sampling technique.…”

Section: Paper-based Microfluidicmentioning

confidence: 99%

Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers

Pour,

Calabria,

Emamiamin

et al. 2024

Biosensors

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Wearable biosensors are attracting great interest thanks to their high potential for providing clinical-diagnostic information in real time, exploiting non-invasive sampling of biofluids. In this context, sweat has been demonstrated to contain physiologically relevant biomarkers, even if it has not been exhaustively exploited till now. This biofluid has started to gain attention thanks to the applications offered by wearable biosensors, as it is easily collectable and can be used for continuous monitoring of some parameters. Several studies have reported electrochemical and optical biosensing strategies integrated with flexible, biocompatible, and innovative materials as platforms for biospecific recognition reactions. Furthermore, sampling systems as well as the transport of fluids by microfluidics have been implemented into portable and compact biosensors to improve the wearability of the overall analytical device. In this review, we report and discuss recent pioneering works about the development of sweat sensing technologies, focusing on opportunities and open issues that can be decisive for their applications in routine-personalized healthcare practices.

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“…The wax printing technique is a useful method for constructing microchannels on paperbased materials by creating hydrophobic barriers [71,72]. The surface of the paper-based material can be modified by using hydrophobic substances such as wax, polydimethylsiloxane (PDMS), or graphite, which penetrate into the micro-pores of the paper during hightemperature baking to block fluid channels and form hydrophobic barriers [73][74][75].…”

Section: Paper-based Sampling Of Non-electrochemical Sweat Sensorsmentioning

confidence: 99%

Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

Yang,

Sun,

Lai

et al. 2023

Biosensors

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Sweat, commonly referred to as the ultrafiltrate of blood plasma, is an essential physiological fluid in the human body. It contains a wide range of metabolites, electrolytes, and other biologically significant markers that are closely linked to human health. Compared to other bodily fluids, such as blood, sweat offers distinct advantages in terms of ease of collection and non-invasive detection. In recent years, considerable attention has been focused on wearable sweat sensors due to their potential for continuous monitoring of biomarkers. Electrochemical methods have been extensively used for in situ sweat biomarker analysis, as thoroughly reviewed by various researchers. This comprehensive review aims to provide an overview of recent advances in non-electrochemical methods for analyzing sweat, including colorimetric methods, fluorescence techniques, surface-enhanced Raman spectroscopy, and more. The review covers multiple aspects of non-electrochemical sweat analysis, encompassing sweat sampling methodologies, detection techniques, signal processing, and diverse applications. Furthermore, it highlights the current bottlenecks and challenges faced by non-electrochemical sensors, such as limitations and interference issues. Finally, the review concludes by offering insights into the prospects for non-electrochemical sensing technologies. By providing a valuable reference and inspiring researchers engaged in the field of sweat sensor development, this paper aspires to foster the creation of innovative and practical advancements in this domain.

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Paper-based microfluidics in sweat detection: from design to application

Abstract: Sweat, as a sample that includes a lot of biochemical information, is good for non-invasive monitoring. In recent years, there has been an increasing number of studies on in situ...

Cited by 5 publications

References 149 publications

Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Microfluidic-Based Non-Invasive Wearable Biosensors for Real-Time Monitoring of Sweat Biomarkers

Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

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