Paper Chromatographic Separation of the Coproporphyrin Isomers I and III

Eriksen, L.

doi:10.1080/00365515809087187

Cited by 30 publications

(10 citation statements)

References 9 publications

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“…After at least 24 hours the esters were transferred to chloroform and further purification was carried out on CaCO, columns. Paper chromatography of the esterified porphyrins was carried out according to Falk and Benson (1953) and isomer separation of the free coproporphyrins according to Eriksen (1958).…”

Section: Urine Saniplesmentioning

confidence: 99%

Interrelationship of Pyrrole and Globin Metabolism in β‐Thalassaemia *

Kreimer‐Birnbaum

Bannerman

1968

Br J Haematol

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Detailed metabolic studies in a case of β‐thalassaemia intermedia following 14C‐2‐glycine administration demonstrate some of the interrelationships of pyrrole pigments and haemoglobins, and some secondary effects of a β‐thalassaemia mutation. Marked increase in the early‐labelled fraction of faecal bile pigment was confirmed; labelling rose to a maximum at 5 days, in advance of the haem peak, and was approximately three times greater than maximum haem labelling. Urinary coproporphyrins were increased in quantity, thus allowing complete serial determinations of radioactivity, which was at its maximum within 24 hours. The urine also contained a brown pigment, probably a dipyrrole, which had a labelling pattern resembling that of the urinary coproporphyrins, with maximum activity in the first sample. It is suggested that the ‘dipyrrole’may arise by early destruction of redundant haem associated with α‐chains. At all times, haemoglobin F was more highly labelled than haemoglobin A in both the haem and the globin moieties. Mean cell survival estimated graphically from the various curves was approximately 32 days. Haem/globin ratios were similar to those reported previously in normal subjects and in thalassaemia.

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Section: Urine Saniplesmentioning

confidence: 99%

Interrelationship of Pyrrole and Globin Metabolism in β‐Thalassaemia *

Kreimer‐Birnbaum

Bannerman

1968

Br J Haematol

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“…After developing the chromatogram according to the method of CHU and CHU (1955), uroporphyrin was diluted with 5 % HCI. Qualitative chromatographic analysis of proto-and coproporphyrin was carried out according to the method described by ERIKSEN (1953ERIKSEN ( , 1958. All porphyrins were quantitatively assayed using spectrophotometry.…”

Section: Methodsmentioning

confidence: 99%

Effects of Concurrent Oral Administration of Lead, Selenium or Monensin on Hepatic Porphyrin Levels in Broiler Chickens During Sub‐acute Toxicosis

Khan¹,

Szarek²

1994

Journal of Veterinary Medicine, Series B

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Liver-porphyrin levels were found to have increased during sub-acute lead toxicosis. The presence of selenium or rnonensin in the diet of lead-intoxicated birds resulted in a further increase of liver-porphyrin levels. The results of this study indicate the presence of an interaction between lead and selenium or monensin in producing an increase in porphyrins in the liver tissue of broiler chickens.

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“…Isomer analysis of free coproporphyrin was done according to Eriksen (1958). Uroporphyrin and 7-carboxylic porphyrins were decarboxylated to coproporphyrin according to Edmondson & Schwartz (1954), prior to isomer analysis.…”

Section: Methodsmentioning

confidence: 99%

Congenital erythropoietic porphyria:A family study

Eriksen

Seip

1973

Clinical Genetics

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We present the results of a study of the porphyrin‐forming enzymes in the erythrocytes of a recently detected case of CBP, in the immediate family, and in the family of a second cousin who died in infancy with a clinical picture similar lo that seen in the present patient. Except for a moderate increase in the activity of the uroporphyrinogen synthetase in the patient's lysates no patological changes have been found either in the patient or in any of the other persons studied. Our findings do not exclude the possibility that impaired activity of the isomerase (uroporphyrinogen‐III‐cosynthetase) plays a role, but they do indicate that this is not the only or even the most important metabolic error in the present type of erythropoictic porphyria. A study of the kinship between the two families seems to make a simple autosomal recessive in. heritance unlikely, hut does not exclude dominant inheritance by a rare single gene with low penetrance carried by the fathers. It is possible that the present case may represent a type of porphyria variegata in which the metabolic defect in porphyrin biosynthesis is located not in the liver hut in the bone marrow.

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Paper Chromatographic Separation of the Coproporphyrin Isomers I and III

Cited by 30 publications

References 9 publications

Interrelationship of Pyrrole and Globin Metabolism in β‐Thalassaemia *

Interrelationship of Pyrrole and Globin Metabolism in β‐Thalassaemia *

Effects of Concurrent Oral Administration of Lead, Selenium or Monensin on Hepatic Porphyrin Levels in Broiler Chickens During Sub‐acute Toxicosis

Congenital erythropoietic porphyria:A family study

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