Architectural heritage is a testament to human and natural development, and the process of human social development can be glimpsed through the study and exploration of heritage. However, in the long history of human social development, architectural heritage is vanishing, and protecting and restoring such heritage is a pressing issue in contemporary society. This study applies the evidence-based theory of medicine to the virtual restoration practice of architectural heritage, which focuses more on scientific data-driven research and decision-making than does traditional restoration. Combined with the practice of evidence-based medicine, the stages of digital conservation of architectural heritage for virtual restoration based on evidence-based design are investigated, forming a comprehensive knowledge system consisting of clear objectives, evidence-based research, evidence assessment, virtual restoration-guided practice, and post feedback. In addition, it is emphasized that the restoration of architectural heritage should be founded on the outcomes obtained through evidence-based practice that have been translated into evidence, in turn creating a rigorous evidence-based system with high-frequency feedback. The final illustration of the procedure is the Bagong House in Wuhan, Hubei Province, China. The examination of this practice line provides a scientific, humanistic, and practicable theoretical framework for the restoration of architectural heritage and fresh ideas for the restoration of other cultural assets, which have significant practical application value.