Paper electrophoresis of gastric juice in health and disease

Glass, George B. Jerzy

doi:10.1007/bf02231812

Cited by 28 publications

(1 citation statement)

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“…Using starch electrophoresis, Katzka (1959) found that instead of four major peaks and five minor peaks as he found in normal patients, the gastric juice of patients with pernicious anaemia showed a central fraction that represented almost all the protein staining material on the electrophoretic strip. Using horizontal paper electrophoresis, Glass (1961) found that the electrophoretic pattern was compressed, being made up of two to four central components, the two most rapidly moving anodal components and the cathodal component being absent. One would have expected the finding of Glass to be similar to ours, as autodigestion was absent in both studies and we have shown that gastric lavage with sodium bicarbonate solution (pH 9) does not alter the electrophoretic pattern of the gastric juice.…”

Section: Resultsmentioning

confidence: 99%

The electrophoresis of human gastric juice: Part III In pernicious anaemia patients

1962

Gut

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The electrophoresis of human gastric juice 357 kept above the upper limit of the pH level at which pepsin exerts proteolytic activity. However, both enzymes could act at different pH levels and pepsin may maintain and perpetuate the ulcer-producing process which may have been initiated by another enzyme. As regards the last mentioned explanation for the presence of band 2, it is theoretically possible that it could result from tryptic digestion from duodenal reflux. This enzyme could be active at the pH of the neutralized gastric contents. This, we feel, is unlikely because amongst the many specimens collected some showed slight to marked biliary reflux (these were excluded from the analysis) and the incidence of band 2 in this group was no higher than in the group that showed no evidence of biliary reflux.

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Section: Resultsmentioning

confidence: 99%