Paper electrophoretic study of ion-pair formation

Fanali, Salvatore; Cardaci, V.; Ossicini, L.

doi:10.1016/s0021-9673(01)96708-1

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…In 1980, Cardaci and Ossicini reported the successful enantioseparation of chiral anions of the type [M(ox) 3 ] 3− [M = Co(III) or Cr(III)] (where ox is oxalate) using solutions of brucine, cinchonine, and quinine acetates as electrolytes under high-voltage paper electrophoresis conditions [25]. In early 1980s, Fanali et al used extensively high-voltage paper electrophoresis and high-performance paper electrophoresis [26], allowing good separation within few minutes, to study the enantioseparation of chiral metal ions like [Co(en 3+ , and [Co(en)(dip) 2 ] 3+ with either antimonyl potassium (+)-tartrate, arsenic sodium (+) tartrate, or (-)-disodium tartrate/AlCl 3 as electrolytes [27,28]. Later, the authors separated other chiral Co(III) complexes by ion pair formation in paper electrophoresis.…”

Section: Enantioseparation Of Co(iii) Cr(iii) Rh(iii) and Pt(iv) Comp...mentioning

confidence: 99%

“…In early 1980s, Fanali et al. used extensively high‐voltage paper electrophoresis and high‐performance paper electrophoresis [26], allowing good separation within few minutes, to study the enantioseparation of chiral metal ions like [Co(en) 3 ] 3+ , [Co(en) 2 ( o ‐phen)] 3+ , [Co(en)( o ‐phen) 2 ] 3+ , [Co( o ‐phen) 3 ] 3+ , [Co(en) 2 (dip)] 3+ , and [Co(en)(dip) 2 ] 3+ with either antimonyl potassium (+)‐tartrate, arsenic sodium (+) tartrate, or (‐)‐disodium tartrate/AlCl 3 as electrolytes [27, 28]. Later, the authors separated other chiral Co(III) complexes by ion pair formation in paper electrophoresis.…”

Section: Enantioseparation Of Co(iii) Cr(iii) Rh(iii) and Pt(iv) Comp...mentioning

confidence: 99%

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Enantioseparation of organometallic compounds by electromigration techniques

Peluso,

Sechi,

Jibuti

2024

Electrophoresis

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Over time, chiral organometallic compounds have attracted great interest in several fields, with applications going across several disciplines of chemical, biological, medical, and material sciences. In the last decades, due to advancements in molecular design and computational modeling, the chemistry of chiral transition metal complexes had a remarkable flowering, with the development of new structures for applications in asymmetric synthesis, bioinorganic chemistry, and molecular recognition. In these fields, fast chiral analysis to determine the enantiomeric purity of organometallic structures prepared by asymmetric synthesis, and for high‐throughput screening of analytes, catalysts, and reactions, is very important. Capillary electrophoresis and related techniques proved to be extremely versatile for chiral analysis, showing unsurpassed advantages compared to chromatography like low consumption of materials, production of limited amounts of waste, fast equilibration, and possibility to replace easily type and concentration of the chiral selector, among others. Furthermore, electromigration techniques may be useful to gain details about the stereochemistry of the enantiomers of new compounds and to study analyte–selector noncovalent interactions at molecular level. On this basis, this short review aims to provide the reader with a comprehensive view on the enantioseparation of organometallic compounds by electromigration techniques, examining the topic from the historical perspective and showing what was made in this field so far, an essential know‐how for developing new and advanced applications in the next future.

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Section: Enantioseparation Of Co(iii) Cr(iii) Rh(iii) and Pt(iv) Comp...mentioning

confidence: 99%

Section: Enantioseparation Of Co(iii) Cr(iii) Rh(iii) and Pt(iv) Comp...mentioning

confidence: 99%

Enantioseparation of organometallic compounds by electromigration techniques

Peluso,

Sechi,

Jibuti

2024

Electrophoresis

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“…Conventional electrophoresis at high voltages( 1000-5000 V) was performed in wetp aper strips (5-10 cm 50 cm), with as elected aqueous solution containing ac hiral selector (e.g.,a ntimony potassium (+)-tartrate) for the enantiomeric separation of some cobalt ethylene diaminec omplexes. [20] Them ain problems encountered were related to the high Joule heat generated during the run, diffusion,a nd adsorption. In our laboratory,t he technique was improved just by modifying the instrumentation, which was namedh igh-performance paper electrophoresis (HPPE).…”

Section: Electromigration Techniquesmentioning

confidence: 99%

Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives

Fanali

2016

Israel Journal of Chemistry

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The separation and analysis of chiral compounds is an important topic of research, because these analytes are involved in various processes, e.g., biological, pharmacological, human health, etc. Their separation has also been recently obtained utilizing microfluidic techniques, such as capillary electrophoresis (CE), electrochromatography (CEC), and capillary/nano‐liquid chromatography (CLC/nano‐LC). Enantiomeric separation is mainly obtained by applying the direct resolution method, where a chiral selector (CS) is present in the separation system, either added to the mobile phase (MP) or bonded to the stationary phase or to the capillary wall. Among the several CSs used in microfluidic techniques, cyclodextrins, proteins, peptides, glycopeptide antibiotics, and modified polysaccharides are the most employed. Microfluidic techniques can offer several advantages over conventional analytical tools, e.g., high efficiency, high mass sensitivity, and reduced volumes of MP and sample. Optimized methods have been applied in different fields, such as biomedical, food chemistry, environment, pharmaceutical, etc. Excellent results have been achieved in CE and nano‐LC. Although CEC can offer higher efficiency due to the use of a strong electroosmotic flow, its use is less popular than the other. This limitation can be explained with the limited number of the stationary phases (SPs) commercially available.

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“…with mixed ligands as well as anionic ones [2][3][4]. This technique can also be used to study the influence of the purity of the chiral selector on the racemic mixture resolution.…”

Section: Optical Isomer Resolution By Hvementioning

confidence: 99%

“…Due to its chemical properties, the modified CD is negatively charged at any commonly used pH in CE. These features allow its use in a charged form over a wide pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Recently this CD has been used successfully for enantiomeric separations of several positively and negatively charged compounds of pharmaceutical interest.…”

Section: Derivativesmentioning

confidence: 99%