These days, we receive most information through digital mediums such as emails and social networking applications. Investigating the characteristics of human-paper interactions can help us design more meaningful interactions and better understand why people use paper documents in the age of digitalization. In this study, the interaction of people with physical documents was studied through a mixed-method of conducting a literature review, gathering expert opinions, interviewing subjects, and analysing Instagram photos. By codifying the gathered information, the human-paper interaction framework was developed. This framework articulates the advantages of physical documents compared to electronic documents and serves researchers and practitioners by providing insightful human factors about human-document interaction. Finally, we propose six design themes as the solutions to the findings of this study. These implications can provide practical foundations for future design and research.