Paper-Supported Photoelectrochemical Biosensor for Dual-Mode miRNA-106a Assay: Integration of Luminescence-Confined Upconversion-Actuated Fluorescent Resonance Energy Transfer and CRISPR/Cas13a-Powered Cascade DNA Circuits
Jiali Huang,
Kang Cui,
Lin Li
et al.
Abstract:Near-infrared (NIR)-responsive bioassays based on upconversion
nanoparticle (UCNP) incorporating high-performance semiconductors
have been developed by researchers, but most lack satisfactory ultrasensitivity
for exceedingly trace amounts of target. Herein, for the first time,
the CRISPR/Cas13a system is combined with cascade DNA circuits, fluorescent
resonance energy transfer (FRET) effect, and luminescence-confined
UCNPs-bonded CuInS2/ZnO p–n heterostructures-functionalized paper-working electrode
to constru… Show more
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