Papillary carcinoma of the thyroglossal duct cyst in a 15-year-old girl

Tan, Geok Chin; Shiran, Mohd Sidik; Swaminathan, Manickam; Phang, K. S.; Clarence-Ko, Ching Huat; Jeevanan, J

doi:10.1016/j.pedex.2007.01.002

Cited by 7 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ninety‐eight articles met the inclusion criteria and were included in the final analysis with a total population of 164 patients. Eighty‐one case reports and 17 case series were included 4–101 . The largest case series included 18 patients, and the studies that we evaluated spanned from 1986 to 2016.…”

Section: Resultsmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Rayess

Monk

Svider

et al. 2017

Otolaryngol.--head neck surg.

115

View full text Add to dashboard Cite

Objective Although thyroglossal duct cysts (TGDCs) are relatively common, malignancies within these lesions are infrequent. As a result, there are no large-scale series describing clinical characteristics. Our objectives were to perform a systematic review of the literature evaluating patient demographics, pathology, management, and prognosis of these patients. Data Sources PubMed, Embase, Cochrane reviews, and Google Scholar were searched for relevant articles. Articles meeting inclusion criteria were reviewed for data detailing epidemiology, treatment, and outcomes. Review Methods Inclusion criteria included English-language articles with original reports on human subjects. Two investigators independently reviewed all articles for the data collected, including epidemiology, treatment, and outcomes. Results Ninety-eight articles comprising 164 patients were included in the final analysis. The mean age at presentation was 39.5 years (9-83 years); 68.3% of patients were female. In total, 73.3% of cases were found on final pathologic analysis. The most common pathology was papillary cancer (92.1%). Of the patients, 98.9% underwent a Sistrunk procedure and 61.0% underwent total thyroidectomy. There was a 4.3% recurrence rate with a mean time to recurrence of 42.1 months from initial treatment. One patient died of TGDC carcinoma, while all other patients were disease free at the time of last follow-up (mean follow-up was 46.1 months). Conclusion TGDC carcinoma is typically diagnosed on final pathology. While management encompasses a Sistrunk procedure, further consideration should be given to thyroidectomy among patients ≥45 years of age and individuals with aggressive disease. TGDC carcinoma harbors an exceedingly low rate of mortality.

show abstract

Section: Resultsmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Rayess

Monk

Svider

et al. 2017

Otolaryngol.--head neck surg.

115

View full text Add to dashboard Cite

show abstract

“…Macroscopically, TGDC carcinomas have a predominantly cystic appearance, although occasionally a mural nodule, solid areas, or papillary excrescences can be appreciated [8,29,30,39,46,53]. Histologically, all reported cases of TGDC carcinomas in the pediatric population have been papillary thyroid carcinomas, a finding quite similar to adults [4].…”

Section: Discussionmentioning

confidence: 96%

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thompson

Herrera

Lau³

2017

Head and Neck Pathol

View full text Add to dashboard Cite

Thyroglossal duct cyst (TGDC) carcinomas are rarely encountered in the pediatric population. The clinical behavior of these tumors in the pediatric setting is unclear and management is not well defined. Two cases of pediatric thyroglossal duct cyst carcinoma were identified in a review of all thyroglossal duct cysts diagnosed over a ten year period. These two cases were analyzed along with 57 cases of thyroglossal duct cyst carcinoma affecting patients less than 21 years of age compiled from the English literature. Fifty-nine patients (36 females, 23 males) aged 6-20 years (mean 15.0 years) were identified. All presented with an anterior midline neck mass, which was typically mobile and non-tender. The average tumor size was 2.6 cm. Histologically, all tumors were papillary thyroid carcinomas arising in a background of a thyroglossal duct cyst. The tumors exhibited a papillary, follicular, or mixed architecture with classical papillary thyroid carcinoma nuclear features. Soft tissue extension was present in 16 cases. All patients were managed surgically with a Sistrunk procedure, with additional thyroidectomy performed in 29 patients, combined with a lymph node dissection (n = 15), or a Sistrunk and lymph node dissection (n = 5). All patients were stage I at presentation, with 11 showing lymph node metastases. Postoperative radioactive iodine was employed in 20 patients. A papillary carcinoma of the thyroid gland was reported in four of the patients who had concurrent/subsequent thyroidectomies. Recurrences were reported in four patients, with distant metastases in one patient, who died of disease (13 months). Follow up data was available for 45 patients, with an overall mean follow-up of 54.5 months. All patients were alive, with the exception of one who died with disease. TGDC carcinomas in pediatric patients is associated with a good overall prognosis, best managed by Sistrunk procedure alone, with selected lymph node dissection if clinically indicated.

show abstract

“…Most of the thyroglossal duct remnants are benign; however, a small percentage of them undergoes neoplastic change. [ 5 ] TDC Carcinoma is uncommon and the incidence varies from 0.7 to 1% of TDC. [ 6 ] It affects women and men at a ratio of 2:1.…”

Section: Discussionmentioning

confidence: 99%

Papillary carcinoma of thyroid in a thyroglossal cyst

Rathod

Rathod²,

Kadam³

2018

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Thyroglossal duct cyst (TDC) is the most common congenital anomaly of the thyroid gland and the most common congenital cervical abnormality in childhood. Carcinoma arising from a TDC is rare, which composes only 1% of TDC cases. Here, we are reporting a case of 50-year-old male with a swelling in the upper left neck region which was progressively increasing in size over 5 years. Ultrasonography report showed a large lobulated cystic mass. Internal echoes with calcification and there were no neck nodes. Thyroid gland was normal. In the present study, the Sistrunk procedure was used to excise a TDC. Papillary carcinoma was confirmed with the histopathological examination following the surgery. The patient was treated with radioactive iodide and thyroid suppression therapy was given as adjuvant treatment. The patient has been following for 2 years without any metastasis.

show abstract

Papillary carcinoma of the thyroglossal duct cyst in a 15-year-old girl

Cited by 7 publications

References 6 publications

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Papillary carcinoma of thyroid in a thyroglossal cyst

Contact Info

Product

Resources

About