Papillary carcinomas of the thyroid have pore‐deficient nuclei

Johannessen, Jan Vincents; Sobrinho‐Simöes, Manuel; Finseth, Inga; Pilström, Lars

doi:10.1002/ijc.2910300405

Cited by 14 publications

(3 citation statements)

References 10 publications

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“…(3,4) state that it is an artifact, but that it has some basis in fact-perhaps peculiar physical and/or chemical properties of the chromatin. Ultrastructural studies of these nuclei have shown finely dispersed chromatin, a highly folded nuclear membrane, and a paucity of nuclear pores (16,17).…”

Section: Introduction the Diagnosis Of Follicular Carcinoma Of The Thmentioning

confidence: 99%

The Demise of Follicular Carcinoma of the Thyroid Gland

LiVolsi¹,

Sylvia²

1994

Thyroid

188

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Over the past several decades, iodide supplementation to food supplies in many parts of the world has been followed by a corresponding decrease in the incidence of follicular thyroid carcinoma. However, pathologists continue to over-diagnose this tumor. Benign lesions (e.g., partly encapsulated hyperplastic nodules, pseudoinvasion after fine needle aspiration), and malignancies (especially the follicular variant of papillary carcinoma) have been misinterpreted as follicular carcinoma. Since the clinical features and biological behavior of true follicular cancer differ from the entities with which it may be confused, it is essential that appropriate histological criteria be applied to the diagnostic interpretation of thyroid nodules that exhibit follicular architecture. Only in this way will it be possible to define prognosis and to evaluate treatment options.

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Section: Introduction the Diagnosis Of Follicular Carcinoma Of The Thmentioning

confidence: 99%

The Demise of Follicular Carcinoma of the Thyroid Gland

LiVolsi¹,

Sylvia²

1994

Thyroid

188

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“…1) and is becoming more readily applied in the clinical setting 154 . There are indications in the literature that higher NPC numbers are associated with more aggressive tumours 155–158 . The quantitative assessment of NPCs is now possible with high-resolution light microscopy (for example, see REF.…”

Section: Applying Knowledge Of the Nuclear Envelopementioning

confidence: 99%

The nuclear envelope environment and its cancer connections

2012

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Because of the association between aberrant nuclear structure and tumour grade, nuclear morphology is an indispensible criterion in the current pathological assessment of cancer. Components of the nuclear envelope environment have central roles in many aspects of cell function that affect tumour development and progression. As the roles of the nuclear envelope components, including nuclear pore complexes and nuclear lamina, are being deciphered in molecular detail there are opportunities to harness this knowledge for cancer therapeutics and biomarker development. In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology.

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“…[37]). In the literature, increases in the number of NPCs were related with more aggressive tumors [38,39,40,41].…”

Section: Introductionmentioning

confidence: 99%

The Biology of the Nuclear Envelope and Its Implications in Cancer Biology

Alvarado-Kristensson

Rosselló

2019

IJMS

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The formation of the nuclear envelope and the subsequent compartmentalization of the genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely viewed as a physical barrier to preserve genetic material in eukaryotic cells. However, in the last few decades, it has been revealed to be a critical cellular component in controlling gene expression and has been implicated in several human diseases. In cancer, the relevance of the cell nucleus was first reported in the mid-1800s when an altered nuclear morphology was observed in tumor cells. This review aims to give a current and comprehensive view of the role of the nuclear envelope on cancer first by recapitulating the changes of the nuclear envelope during cell division, second, by reviewing the role of the nuclear envelope in cell cycle regulation, signaling, and the regulation of the genome, and finally, by addressing the nuclear envelope link to cell migration and metastasis and its use in cancer prognosis.

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Papillary carcinomas of the thyroid have pore‐deficient nuclei

Cited by 14 publications

References 10 publications

The Demise of Follicular Carcinoma of the Thyroid Gland

The Demise of Follicular Carcinoma of the Thyroid Gland

The nuclear envelope environment and its cancer connections

The Biology of the Nuclear Envelope and Its Implications in Cancer Biology

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