Papillary cystadenocarcinoma of the sublingual gland presenting as a ranula

Danford, M.; Flood, T.R.; Eveson, J.W.

doi:10.1016/0266-4356(92)90274-m

Cited by 31 publications

(5 citation statements)

References 16 publications

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“…Although both LG-SDC and cystadenocarcinomas share a cystic appearance, cystadenocarcinomas are clearly infiltrative neoplasms which lack cribriform architecture and non-neoplastic myoepithelial cells when stained with SMA, MSA, and other myoepithelial markers [17][18][19][20]. Given the relatively recent description of LG-SDC, we could speculate that some putative examples of low-grade ''cystadenocarcinoma'' in reality represent LG-SDC [17,25].…”

Section: Cystadenocarcinomamentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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Section: Cystadenocarcinomamentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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“…[7,12,14] In contrast, reports about CACs of the sublingual glands are exceedingly rare. [3] A review of the literature revealed only 3 single case reports of sublingual gland CAC, as well as 2 additional cases included in the series of Foss et al [4,6,9,15] [ Table 1] In general, salivary gland CACs are uncommon representing only a small minority of all salivary gland tumors. [3] Unlike salivary glands, CACs are relatively frequent in other organs, such as the mammary gland, the bile ducts, the pancreas and the ovaries.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Imaging techniques, such ultrasound, CT and magnetic resonance imaging, may provide valuable information regarding the origin of a tumor in the sublingual area. [10] Determination of the exact site of development as well as definitive diagnosis relies upon surgical removal and histopathologic examination.…”

Section: Discussionmentioning

confidence: 99%

Papillary cystadenocarcinoma of the sublingual gland: case report and literature review

Paschalidi¹,

Nikitakis²,

Igoumenakis³

et al. 2017

SDS

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Papillary cystadenocarcinoma (CAC) a rare malignant salivary gland tumor which commonly arises in the major glands, mainly the parotid, and less frequently in the minor salivary glands. Localization in the sublingual salivary gland is very rare. The authors present a case of papillary CAC originating from the right sublingual gland in a 78-year-old female. A review of the literature revealed only 3 previously published detailed cases (in addition to 2 cases as part of larger series) of papillary CAC of the sublingual gland. The salient demographic, clinical, and histopathologic findings of papillary CAC, as well as its surgical treatment, are discussed. Key words:Papillary cystadenocarcinoma, sublingual gland, cystic structures ABSTRACT Article history:

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO. [13][14][15][16][17][18][19] Signet ring carcinomas composed of discohesive cells with intracellular mucin vacuoles have also rarely been described. [20][21][22] However, the 2017 WHO Classification of Head and Neck Tumours grouped all of these, along with many entirely dissimilar tumors, into the broad adenocarcinoma not otherwise specified (NOS) category with the rationale that mucinous differentiation was a nonspecific feature.…”

mentioning

confidence: 99%

“…Tumors with colloid architecture, defined by malignant cells floating in lakes of extracellular mucin, were recognized as a standalone entity under the name mucinous adenocarcinoma in the 2005 World Health Organization (WHO) Classification of Head and Neck Tumours 1–13. Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO 13–19. Signet ring carcinomas composed of discohesive cells with intracellular mucin vacuoles have also rarely been described 20–22.…”

mentioning

confidence: 99%

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

Rooper

Argyris

Thompson

et al. 2021

American Journal of Surgical Pathology

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Mucin-producing salivary adenocarcinomas were historically divided into separate colloid carcinoma, papillary cystadenocarcinoma, and signet ring cell carcinoma diagnoses based on histologic pattern, but have recently been grouped together in the adenocarcinoma not otherwise specified category. It is currently unclear if these tumors represent 1 or more distinct entities and how they are related to well-circumscribed papillary mucinous lesions with recurrent AKT1 E17K mutations that were recently described as salivary intraductal papillary mucinous neoplasm. Here, we sought to evaluate the clinicopathologic and molecular features of salivary mucinous adenocarcinomas to clarify their classification. We identified 17 invasive mucin-producing salivary adenocarcinomas, 10 with a single histologic pattern, and 7 with mixed patterns. While most tumors demonstrated papillary growth (n=15), it was frequently intermixed with colloid (n=6) and signet ring (n=3) architecture with obvious transitions between patterns. All were cytokeratin 7 positive (100%) and cytokeratin 20 negative (0%). Next-generation sequencing performed on a subset demonstrated recurrent AKT1 E17K mutations in 8 cases (100%) and TP53 alterations in 7 cases (88%). Of 12 cases with clinical follow-up (median: 17 mo), 4 developed cervical lymph node metastases, all of which had colloid or signet ring components. Overall, overlapping histologic and immunohistochemical features coupled with recurrent AKT1 E17K mutations across patterns suggests that mucin-producing salivary adenocarcinomas represent a histologically diverse single entity that is closely related to tumors described as salivary intraductal papillary mucinous neoplasm. We propose a unified mucinous adenocarcinoma category subdivided into papillary, colloid, signet ring, and mixed subtypes to facilitate better recognition and classification of these tumors.

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Papillary cystadenocarcinoma of the sublingual gland presenting as a ranula

Cited by 31 publications

References 16 publications

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Papillary cystadenocarcinoma of the sublingual gland: case report and literature review

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

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