Papillary cystadenoma lymphomatosum (Adenolymphoma)

Chaudhry, Anand P.; Gorlin, Robert J.

doi:10.1016/0002-9610(58)90835-3

Cited by 62 publications

(12 citation statements)

References 38 publications

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“…Analysis of the literature involving nearly 1,700 cases of Warthin's tumor [4][5][6][7][8] shows that this lesion accounts for approximately 5-6% of salivary lesions, arises almost exclusively within the parotid gland, grows slowly, and is typically detected at an average age of 55 years. A steady increase in the incidence among women is also reported since the 1930s, but there is still a clear male predominance.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle sampling of salivary gland lesions II. Cytology and histology correlation of 71 cases of Warthin's tumor (adenolymphoma)

Klijanienko¹,

Vielh²

1997

Diagn. Cytopathol.

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Fine‐needle sampling (FNS) of 71 Warthin's tumors was performed preoperatively in 70 patients. Cytologic diagnoses were concordant with histology in 50 (70.4%) tumors, whereas 14 (19.7%) cases were cytologically misclassified as benign lesions. Material for cytologic evaluation was unsatisfactory in seven (9.9%) cases, and no suspicious or false‐positive diagnoses were observed. FNS is therefore a reliable preoperative technique for assessment of Warthin's tumor with a concordant/benign diagnostic rate of 90.1%. Diagn. Cytopathol. 16:221–225, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Fine-needle sampling of salivary gland lesions II. Cytology and histology correlation of 71 cases of Warthin's tumor (adenolymphoma)

Klijanienko¹,

Vielh²

1997

Diagn. Cytopathol.

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“…Three parotid tumors (Warthin's tumor or papillary cystadenoma lymphomatosum [PCL]) were studied (16). This type of parotid tumor is particularly interesting since it consists of columnar epithelial cells overlying a dense lymphoid infiltrate (16)(17)(18).…”

Section: Methodsmentioning

confidence: 99%

Expression of histocompatibility antigen HLA—DR by salivary gland epithelial cells in Sjögren's syndrome

Fox

Bumol

Fantozzi

et al. 1986

Arthritis & Rheumatism

113

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Recent studies have suggested that the induction of HLA—DR antigens on epithelial cells plays an important role in the pathogenesis of autoimmune endocrine‐exocrine disorders. We found that salivary gland epithelial cells (i.e., acinar and ductal cells) in salivary gland biopsy specimens from patients with primary Sjögren's syndrome (keratoconjunctivitis sicca) expressed high levels of HLA—DR antigen, which were detected by staining frozen tissue sections with monoclonal antibodies and immunoperoxidase technique. In contrast, salivary gland epithelial cells from normal subjects did not express this antigen. Lymphocytes eluted from the salivary gland biopsy specimens of patients who had Sjögren's syndrome produced a soluble factor that stimulated HLA—DR synthesis by a salivary gland‐derived cell line (Sal‐1). These tissue culture supernatants contained γ‐interferon, and their ability to induce HLA—DR synthesis was blocked by monoclonal anti‐γ‐interferon antibody. These results demonstrate the presence of HLA—DR antigen on salivary gland epithelial cells and suggest that local production of γ‐interferon plays a role in this induction.

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“…Papillary cystademona refers to the double-layer epithelium with papillary bumps inside the cystoma, whereas lymphomatosum pertains to the lymphal tissues surrounding and supporting the tumor. Warthin became the first to substantiate this tumor, which has been widely known as Warthin's tumor -a designation that is easy to use -since then 2 . This type of tumor is the second most common after pleomorphic adenoma among other benign tumors found in the salivary glands.…”

Section: Introductionmentioning

confidence: 99%

“…parotid gland was parotid tail, followed by the anterior margin of the ear lobe. It is at times found in the mouth, mostly in the palate or buccal mucosa 2,9 . It is often multicentric and bilateral (10-30% and 5-9%, respectively).…”

Section: Introductionmentioning

confidence: 99%

Warthin's tumor of the parotid gland: a case report

Kim

Han

Kim

2012

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2012;38:366-70) Initially described in 1929, Warthin's tumor is a benign neoplasm predominantly found in the parotid gland of the salivary glands. Warthin's tumor is synonymous for cystadenoma lymphomatosum, adenolymphoma, and cystadenolymphoma. This tumor usually causes minimal pain, but the patient may complain of tinnitus, pain in the ear, or deafness. The tumor is treated with surgical excision, which is easily performed due to the superficial location of the tumor. In our case, a 69-year-old man visited our clinic primarily complaining of swelling in the left parotid gland area. Computed tomography revealed well-defined margins of the tumor in the superficial lobe of the left parotid gland and heterogeneous contrast enhancement. We performed superficial parotidectomy, with the pathological examination confirming Warthin's tumor. We report a typical case of Warthin's tumor and a literature review.

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Papillary cystadenoma lymphomatosum (Adenolymphoma)

Cited by 62 publications

References 38 publications

Fine-needle sampling of salivary gland lesions II. Cytology and histology correlation of 71 cases of Warthin's tumor (adenolymphoma)

Fine-needle sampling of salivary gland lesions II. Cytology and histology correlation of 71 cases of Warthin's tumor (adenolymphoma)

Expression of histocompatibility antigen HLA—DR by salivary gland epithelial cells in Sjögren's syndrome

Warthin's tumor of the parotid gland: a case report

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