Papillary-Cystic Variant of Acinic Cell Carcinoma in the Lacrimal Gland

Bannister, Miles; Lawson, Greig

doi:10.1155/2014/285485

Cited by 2 publications

(3 citation statements)

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“…Only four other cases of acinic cell carcinoma in the lacrimal gland have been reported in patients from 18 to 78 years of age (Table 2, Table 3) [32, 33, 34, 35] and one case was present in case series of Verdijk et al [36]. Two of these lesions showed a benign clinical behavior, while two proved to be aggressive, characterized by histopathological infiltrative comportment: bone involvement, intracranial extensions and local recurrence (Table 2, Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…Focusing on surgical treatment for AcCC of the lacrimal gland, we can note that the tumor extent in the case reported by Rosenbaum [33] required an orbital exenteration because of globe and eyelid involvement. Orbital exenteration is related to high morbidity, but according to the seventh and eighth edition of the AJCC staging system, T number (T2) in Rosenbaum ' s case [33] is analogue to T scoring in De Rosa ' s case [32], in Bannister and Lawson ' s case [35], and in the case here presented, in all of which orbital sparing surgery was successfully used and not orbital exenteration. In conclusion, the correlation between high T score and wide surgical excision (exenteration orbitae) is not strong for AcCC and for other low grade carcinomas of the lacrimal gland, in both last two editions of the AJCC staging system manual lacrimal gland carcinoma staging system.…”

Section: Figmentioning

confidence: 99%

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Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland

et al. 2019

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To report a case of acinic cell carcinoma occurred in the lacrimal gland. A 59-year-old man was admitted because of sudden blurring of vision, progressive proptosis of the left eye, and mild double vision in left and down directions of the gaze (Hess-Lancaster test). His medical history detailed controlled bilateral keratoconus and open angle glaucoma. On examination, the best corrected visual acuity decreased from 8/20 till 1/50 in one week. There was a swelling of the left upper eyelid. A hard and tender mass was palpated in the superior temporal left orbit. Ultrasound scan showed an extraconal solid mass, situated in the superior lateral corner of the orbit. Computed tomography and magnetic resonance imaging (MRI) revealed a mass of two centimeters in diameter, with round well-defined outline, within the lacrimal gland. We performed an enucleoresection of the mass, via a coronal approach and a lateral orbitotomy by a piezosurgical device. The lesion appeared nodular, brownish, measuring about 2 × 1.5 cm. Histopathological findings were consistent with acinic cell carcinoma with a microcystic, focally papillary-cystic growth of pattern. Follow-up MRI outcomes led to removal of the residual lacrimal gland for suspicion of recurrence. No tumor recurrences where detected at 7-year follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland

et al. 2019

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“…Risk factors for acinic cell carcinoma are not yet clear but could include previous radiation exposure and familial predisposition [19]. Acinic cell carcinoma in a lacrimal gland tumor was first described by De Rosa et al in 1986, and the few cases documented since in humans and animals have been shown to exhibit aggressive behavior in association with poor prognosis [20–25]. In the current study, the disease manifested as exophthalmos and was confirmed by radiographic examination and further histopathological and immunohistochemical analysis.…”

Section: Discussionmentioning

confidence: 99%

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland

Kim

Baek

Park

et al. 2018

Analytical Cellular Pathology

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Environmental and genetic factors exert important influences on lifespan and neoplastic transformation. We have previously shown that spontaneous tumors form frequently in mice homozygous for a full-length Brca1 deletion. In general, mutations of BRCA1 are closely associated with induction of breast and ovarian cancers but are also known to contribute to the incidence of other cancers at a low frequency. Female Brca1-mutant mice (Brca1co/coMMTV-cre) were generated by crossing Brca1 conditional knockout mice and MMTV-cre mice, and the occurrence of lacrimal gland abnormalities and tumors was followed until mice reached 18 months of age. Lacrimal gland tumors, which occur at a very low frequency in the human population (1 per 1,000,000 per year), were detected in 7 cases of Brca1co/coMMTV-cre mice (2.75%) older than 9 months of age. None of seven mice exhibited any abnormality in the mammary gland including neoplasia, suggesting lacrimal gland tumor is spontaneously and independently formed. These tumors, which were detected in seven mutant mice that displayed exophthalmoses, were malignant, originated from epithelial cells, and were identified as acinic cell carcinoma by pathological analysis. Further analysis revealed that tumorigenesis was accompanied by the accumulation of cyclin D1 and decreased expression of the cellular oncogenes, c-Myc, c-Jun, and c-Raf. Tumors also exhibited rearrangement of cytoskeletal proteins, including β-catenin, keratin 5, and vimentin, depending on tumor progression. These results suggest that BRCA1 is involved in genetic stability of the lacrimal gland, providing new insight into genomic instability in organism maintenance and tumorigenesis of the lacrimal gland.

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Papillary-Cystic Variant of Acinic Cell Carcinoma in the Lacrimal Gland

Cited by 2 publications

References 10 publications

Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland

Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland

Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland

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