Papillary eccrine adenoma-a light-microscopic and immunohistochemical study

Requkna, L.; López-Peña, Mónica; Sánchez, Mónica Torres; Yus, Evaristo Sánchez

doi:10.1111/j.1365-2230.1990.tb02136.x

Cited by 16 publications

(8 citation statements)

References 20 publications

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“…However, there is disagreement about the direction of differentiation (2), and authors variously favor a ductal (13)(14)(15), a glandular (16,17), or a dual ductalglandular (18) differentiation. Many authors have proposed theories based on the presence of SlOO protein detected by immunohistochemical staining with polyclonal antibody against SlOO protein (14)(15)(16)(17). However, there are different conclusions about the cellular differentiation of PEA because SlOO protein has not been consistently demonstrated in PEA.…”

Section: Discussionmentioning

confidence: 99%

Papillary eccrine adenoma: immunohistochemical studies of keratin expression

et al. 1997

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Despite various studies, there are serious disagreements about the cellular differentiation of papillary eccrine adenoma. In the present study, 2 specimens of papillary eccrine adenoma were analyzed by immunohistochemical techniques, using a panel of monoclonal antibodies against keratins, to elucidate its differentiation. Histopathologically, the tumor was composed of multiple tubular structures lined by two or more layers of epithelial cells. The luminal cells of the tubules were flattened or cuboidal. The former were noted in large dilated tubules. The latter were usually observed in small-to-moderate-sized tubules, and formed intraluminal papillary projections in some tubules. Immunohistochemically, there were two kinds of cuboidal cells in the luminal layers of the tubules. Most of the large dilated tubules and some of the small-to-moderate-sized tubules expressed immunophenotypes similar to those of the eccrine dermal duct. The other tubular structures, including the small tubules resembling those of syringoma, expressed immunophenotypes similar to those of the transitional portions between the dermal ducts and the secretory segments of eccrine glands. From the above comparative studies, papillary eccrine adenoma is considered to differentiate towards the dermal duct and the transitional portions between the dermal ducts and the secretory segments of eccrine glands.

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Section: Discussionmentioning

confidence: 99%

Papillary eccrine adenoma: immunohistochemical studies of keratin expression

et al. 1997

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“…A connection to the epidermis or infundibulum has often been demonstrated in published cases of TA, yet these lesions were variously interpreted as PEA or TAA, not as SCAP. [1][2][3]9,14,[18][19][20][21][22][23][24][25][26][27][28] Connection of the tumors to the infundibulum has been used by some authorities as an argument to support apocrine differentiation. 2,3 One of the observers diagnosed a lesion in this series as SCAP even if it exhibited a single focus in which glandular elements were in continuity to the follicular infundibulum (Fig.…”

Section: Discussionmentioning

confidence: 99%

Tubular Adenoma and Syringocystadenoma Papilliferum: A Reappraisal of Their Relationship. An Interobserver Study of a Series, by a Panel of Dermatopathologists

Kazakov¹,

Bisceglia²,

Calonje³

et al. 2007

The American Journal of Dermatopathology

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Tubular adenoma (TA) and syringocystadenoma papilliferum (SCAP) may show histopathological overlap, with some lesions having features of both neoplasms (SCAP + TA). TA has been recently suggested to represent a carcinoma. Four observers blindly assessed 67 cases of TA, SCAP, and their lookalikes (poroma, apocrine adenoma, apocrine carcinoma; all lesions focally featuring a pseudopapillary pattern), and classified the lesions into one of four categories: (1) TA, (2) SCAP, (3) SCAP + TA, and (4) others. Lesions were also classified as benign or malignant. In only 29 cases was there unanimous agreement among the four observers, who classified 22 lesions as TA, three as SCAP, and four cases as others. Of the 38 cases where there was interobserver diagnostic variation, in 30, the diagnosis varied between TA or SCAP or SCAP + TA; the remainder fell in the others category. Analysis of the factors leading to interobserver variability indicated that diagnostic problems occurred when there were any of the following: epidermal acanthosis, papillomatosis, connection of the neoplastic tubules to the overlying epidermis and/or follicular infundibula, and plasma cell infiltration. These features accounted for the morphological overlap between TA and SCAP. All observers agreed that the lesions were benign; the only apocrine carcinoma included was recognized as such by all observers. From the study, it was concluded that TA may arise in the deep dermis without any epidermal connection, or, in other cases, it may be more superficially located with or without an epidermal connection. It may be reasonably inferred that, possibly as a response to infection, there may be accompanying plasma cells and variable acanthosis and papillomatosis, such that the appearances are those of "pure" SCAP, or lesions may have features "intermediate" or overlapping between TA and SCAP.

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“…[18][19][20][21][22][23][24][25][26] Squamous metaplasia has only rarely been specifically commented upon in the previously published material on tubular apocrine adenoma/papillary eccrine adenoma, although the descriptions of solid epithelial nodules, dilated cysts containing laminated keratin or squamous-cell-lined cysts almost certainly correspond to this phenomenon. [27][28][29][30] Murphy and Elder 30 suggested that dilated cysts containing laminated keratin may represent recapitulation of intraepidermal eccrine duct formation. Because an otherwise well-formed basal/ myoepithelial cell layer was not visible in the nodules that had fully undergone squamous metaplasia, we suggest that hyperplasia and/or metaplasia of basal/myoepithelial cells is responsible for the remarkable immature and mature squamous cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

Tubular Adenoma of the Skin with Follicular and Sebaceous Differentiation

Kazakov

Mukenšnábl

Michal

2006

The American Journal of Dermatopathology

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The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues. We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation. The features in both cases indicated apocrine differentiation of the tubular component. One patient was a 60-year-old woman with a 1-year history of a solitary nodule on the scalp. The other patient was a 48-year-old woman with a solitary nodule of unknown duration located on the back. In both patients, the tumors were surgically removed. The patients were alive and well 2.5 and 2 years after surgery, respectively. The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia. In case 1, follicular differentiation was seen in the form of strands of basaloid cells surrounded by a stroma resembling the embryonic perifollicular sheath. Some aggregates of basaloid cells were juxtaposed with small collections of plump fibroblasts, imparting a resemblance to rudimentary follicular germs associated with follicular papillae. Many minute lumens surrounded by more eosinophilic cells were seen within the strands. In case 2, follicular differentiation was seen as several infundibulocystic structures surrounded by isthmic epithelium housing scattered mature sebocytes. In addition, there were areas reminiscent of desmoplastic trichoepithelioma (columnar trichoblastoma). In both cases, the areas with immature squamous metaplasia were represented by solid nodules that were mostly devoid of lumens and a peripheral basal/myoepithelial cell layer. In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation. Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart.

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Papillary eccrine adenoma-a light-microscopic and immunohistochemical study

Cited by 16 publications

References 20 publications

Papillary eccrine adenoma: immunohistochemical studies of keratin expression

Papillary eccrine adenoma: immunohistochemical studies of keratin expression

Tubular Adenoma and Syringocystadenoma Papilliferum: A Reappraisal of Their Relationship. An Interobserver Study of a Series, by a Panel of Dermatopathologists

Tubular Adenoma of the Skin with Follicular and Sebaceous Differentiation

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