“…Because they are viewed more as clinical curiosities than as bona fide cardiac pathologies, with the primary treatment consisting of surgical excision, the literature concerning papillary fibroelastomas has largely consisted of clinical series and case reports of unusual locations and manifestations, 1,2 such as the report in this issue of the Journal by Popovic and colleagues. 3 What distinguishes this case report from others, however, is its description of recurrence of a valve-based (aortic valve) papillary fibroelastoma to a ''distant'' nonvalvular site (left ventricle). This finding is inconsistent with the notions that these lesions are benign and may not even be true neoplasms but rather hamartomas or reactive changes of normal tissue.…”